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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (03) : 307 -312. doi: 10.3877/cma.j.issn.1674-1358.2018.03.021

所属专题: 经典病例 经典病例 文献

病例报告

人类获得性免疫缺陷综合征合并播散性马尔尼菲青霉菌病和噬血细胞综合征一例并文献复习
王中涛1, 熊勇1,(), 邓莉平1, 田素芳2, 陈飞3   
  1. 1. 430071 武汉市,武汉大学中南医院感染科
    2. 430071 武汉市,武汉大学中南医院病理科
    3. 430071 武汉市,武汉大学中南医院血液内科
  • 收稿日期:2017-09-11 出版日期:2018-06-15
  • 通信作者: 熊勇

A case of acquired immune deficiency syndrome complicated with disseminated penicilliosis marneffei and hemophagocytic syndrome and the literature review

Zhongtao Wang1, Yong Xiong1,(), Liping Deng1, Sufang Tian2, Fei Chen3   

  1. 1. Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
    2. Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
    3. Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  • Received:2017-09-11 Published:2018-06-15
  • Corresponding author: Yong Xiong
  • About author:
    Corresponding author: Xiong Yong, Email:
引用本文:

王中涛, 熊勇, 邓莉平, 田素芳, 陈飞. 人类获得性免疫缺陷综合征合并播散性马尔尼菲青霉菌病和噬血细胞综合征一例并文献复习[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(03): 307-312.

Zhongtao Wang, Yong Xiong, Liping Deng, Sufang Tian, Fei Chen. A case of acquired immune deficiency syndrome complicated with disseminated penicilliosis marneffei and hemophagocytic syndrome and the literature review[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(03): 307-312.

目的

提高对人类获得性免疫缺陷综合征(AIDS)合并播散性马尔尼菲青霉菌病(PSM)、噬血细胞综合征(HPS)和组织细胞坏死性淋巴结炎(HNL)的认识。

方法

分析1例AIDS合并播散性PSM、HPS以及HNL(疑诊)的诊疗过程,并结合相关文献进行复习。

结果

1例43岁男性AIDS合并播散性PSM、HPS以及HNL(疑诊)患者,给予综合抗感染、抗炎(小剂量地塞米松)、护肝及对症支持治疗后,患者体温恢复正常,病情稳定出院。

结论

早期诊断及治疗PSM、HPS、HNL是降低患者病死率及改善预后的关键。

Objective

To enhance the awareness on acquired immune deficiency syndrome (AIDS) complicated with disseminated penicilliosis marneffei (PSM), hemophagocytic syndrome (HPS) and histocytic necrotizing lymphadenitis (HNL).

Methods

The process of diagnosis and treatment of one AIDS patients complicated with disseminated PSM, HPS and HNL (suspected) was analyzed. The relevant literatures were reviewed.

Results

One 43 years old man with AIDS complicated with disseminated PSM, HPS and HNL (suspected) was enrolled and treated by comprehensive anti-infection, anti-inflammatory (low dose dexamethasone), liver protection and symptomatic support. The patient recovered normal temperature and discharged in stable condition after treatment.

Conclusions

Early diagnosis and treatment of PSM, HPS and HNL are the keys to reduce the mortality and improve the prognosis for patients.

图1 患者两次胸部CT图片
图2 患者两次骨穿图片(瑞氏染色,× 1 000)
图3 2017年2月8日患者颈部淋巴结病理活检
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