Cutaneous manifestations associated with severe acute respiratory syndrome coronavirus 2 among pediatrics

doi:10.3877/cma.j.issn.1674-1358.2021.06.003

Abstract

Abstract:

Cutaneous manifestations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported continuously. In this review, the types and characteristics of different skin lesions of COVID-19 children were summarized, and its pathological mechanism, differential diagnosis, treatment and prognosis were analyzed, so as to enrich the clinicians’ cognition of SARS-CoV-2 associated cutaneous manifestation, inorder to achieve early identification and treatment.

Key words: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Infection, Pediatrics, Cutaneous manifestations

Yixing Meng, Hui Huang, Li Deng. Cutaneous manifestations associated with severe acute respiratory syndrome coronavirus 2 among pediatrics[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2021, 15(06): 374-378.

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References 39

[1]	Pousa PA, Mendonca TSC, Oliveira EA, et al. Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations[J]. J Pediatr (Rio J),2021,97(2):116-139.
[2]	Lu S, Lin J, Zhang Z, et al. Alert for non-respiratory symptoms of coronavirus disease 2019 patients in epidemic period: A case report of familial cluster with three asymptomatic COVID-19 patients[J]. J Med Virol,2021,93(1):518-521.
[3]	Recalcati S. Cutaneous manifestations in COVID-19: a first perspective[J]. J Eur Acad Dermatol Venereol,2020,34(5):e212-e213.
[4]	Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China[J]. N Engl J Med,2020,382(18):1708-1720.
[5]	Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7 780 pediatric patients: A systematic review[J]. E Clinical Medicine,2020,24:100433.
[6]	Chen Y, Peng H, Wang L, et al. Infants born to mothers with a new coronavirus (COVID-19)[J]. Front Pediatr,2020,8:104.
[7]	Wu P, Liang L, Chen C, et al. A child confirmed COVID-19 with only symptoms of conjunctivitis and eyelid dermatitis[J]. Graefes Arch Clin Exp Ophthalmol,2020,258(7):1565-1566.
[8]	Khalili M, Iranmanesh B, Mohammadi S, et al. Cutaneous and histopathological features of coronavirus disease 2019 in pediatrics: A review article[J]. Dermatol Ther,2021,34(1):e14554.
[9]	Andina D, Noguera-Morel L, Bascuas-Arribas M, et al. Chilblains in children in the setting of COVID-19 pandemic[J]. Pediatr Dermatol,2020,37(3):406-411.
[10]	Garcia-Lara G, Linares-Gonzalez L, Rodenas-Herranz T, et al. Chilblain-like lesions in pediatrics dermatological outpatients during the COVID-19 outbreak[J]. Dermatol Ther,2020,33(5):e13516.
[11]	Riphagen S, Gomez X, Gonzalez-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic[J]. Lancet,2020, 395(10237):1607-1608.
[12]	World Health Organization. Multisystem inflammatory syndrome in children and adolescents with covid-19[EB/OL]. URL
[13]	Centers for Disease Control and Prevention. Emergency preparedness and response: mulisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19)[EB/OL]. URL
[14]	Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem inflammatory syndrome in U.S. children and adolescents[J]. N Engl J Med,2020, 383(4):334-346.
[15]	Pouletty M, Borocco C, Ouldali N, et al. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort[J]. Ann Rheum Dis,2020,79(8):999-1006.
[16]	Galvan Casas C, Catala A, Carretero Hernandez G, et al. Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases[J]. Br J Dermatol,2020,183(1):71-77.
[17]	Morey-Olive M, Espiau M, Mercadal-Hally M, et al. Cutaneous manifestations in the current pandemic of coronavirus infection disease (COVID 2019)[J]. An Pediatr (Engl Ed),2020,92(6):374-375.
[18]	Daneshgaran G, Dubin DP, Gould DJ. Cutaneous Manifestations of COVID-19: An Evidence-Based Review[J]. Am J Clin Dermatol,2020,21(5):627-639.
[19]	Torrelo A, Andina D, Santonja C, et al. Erythema multiforme-like lesions in children and COVID-19[J]. Pediatr Dermatol,2020,37(3): 442-446.
[20]	Olisova OY, Anpilogova EM, Shnakhova LM. Cutaneous manifestations in COVID-19: A skin rash in a child[J]. Dermatol Ther,2020,33(6):e13712.
[21]	Klimach A, Evans J, Stevens J, et al. Rash as a presenting complaint in a child with COVID-19[J]. Pediatr Dermatol,2020,37(5):966-967.
[22]	Jia JL, Kamceva M, Rao SA, et al. Cutaneous manifestations of COVID-19: A preliminary review[J]. J Am Acad Dermatol,2020,83(2): 687-690.
[23]	Genovese G, Colonna C, Marzano AV. Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: A diagnostic clue?[J].Pediatr Dermatol,2020,37(3):435-436.
[24]	孙芬芬, 贺斌峰, 何勇. 血管紧张素转化酶2在冠状病毒感染所致肺损伤及其他肺部疾病中研究进展[J/CD]. 中华实验和临床感染病杂志(电子版),2021,15(1):7-10.
[25]	Ortiz-Fernandez L, Sawalha AH. Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations[J]. Genes Immun,2020,21(4):269-272.
[26]	Colmenero I, Santonja C, Alonso-Riano M, et al. SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatriccases[J]. Br J Dermatol,2020,183(4):729-737.
[27]	Fu Y, Cheng Y, Wu Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools[J]. Virol Sin,2020,35(3):266-271.
[28]	Schnapp A, Abulhija H, Maly A, et al. Introductory histopathological findings may shed light on COVID-19 paediatrichyperinflammatory shock syndrome[J]. J Eur Acad Dermatol Venereol,2020,34(11):e665-e667.
[29]	Rodriguez-Jimenez P, Chicharro P, De Argila D, et al. Urticaria-like lesions in COVID-19 patients are not really urticaria--a case with clinicopathologicalcorrelation[J]. J Eur Acad Dermatol Venereol,2020,34(9):e459-e460.
[30]	El Hachem M, Diociaiuti A, Concato C, et al. A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infection[J]. J Eur Acad Dermatol Venereol,2020,34(11):2620-2629.
[31]	Mahe A, Birckel E, Merklen C, et al. Histology of skin lesions establishes that the vesicular rash associated with COVID-19 is not 'varicella-like’[J]. J Eur Acad Dermatol Venereol,2020,34(10): e559-e561.
[32]	Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study[J]. Lancet,2020,395(10239): 1771-1778.
[33]	Capocasale G, Nocini R, Faccioni P, et al. How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease[J]. ClinExp Dent Res,2021,7(1):101-108.
[34]	Diociaiuti A, Giancristoforo S, Terreri S, et al. Are SARS-CoV-2 IgA antibodies in paediatric patients with chilblain-like lesions indicative of COVID-19 asymptomatic or paucisymptomaticinfection[J]. J Eur Acad Dermatol Venereol,2021,35(1):e10-e13.
[35]	Fernandez-Nieto D, Ortega-Quijano D, Jimenez-Cauhe J, et al. Clinical and histological characterization of vesicular COVID-19 rashes: a prospective study in a tertiary care hospital[J]. Clin Exp Dermatol,2020,45(7):872-875.
[36]	Cepeda-Valdes R, Carrion-Alvarez D, Trejo-Castro A, et al. Cutaneous manifestations in COVID-19: familial cluster of urticarial rash[J]. Clin Exp Dermatol,2020,45(7):895-896.
[37]	Proietti I, Mambrin A, Bernardini N, et al. Urticaria in an infant with SARS-CoV-2 positivity[J]. Dermatol Ther,2020,33(6):e14043.
[38]	Burgi Vieira C, Ferreira AT, Botelho Cardoso F, et al. Kawasaki-like syndrome as an emerging complication of SARS-CoV-2 infection in young adults[J]. Eur J Case Rep Intern Med,2020,7(10):001886.
[39]	张炎, 曹玮, 肖盟, 等. 合并肢端缺血表现的危重型新型冠状病毒肺炎七例临床分析[J]. 中华血液学杂志,2020,41(4):302-307.

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