Hepatitis C virus (HCV) core protein binding protein 6 (HCBP6) is first identified by Professor Cheng Jun’s team as a protein binding to HCV core protein with the yeast two hybrid system. Professor Cheng’s team further found that HCBP6 can sensor the fluctuation of total cholesterol and triglyceride and help to maintain the homeostasis of lipid metabolism and glycometabolism. Homozygous HCBP6 knock-out mouse showed abnormal lipid metabolism and glycometabolism on high fat diet feeding. Professor Cheng’s team found that PTIB001 from Korean red ginseng might help to maintain homeostasis of lipid metabolism and glycometabolism through HCBP6 pathway. Professor Cheng’s team enhanced the development of functional food which contain PTIB001 for nonalcoholic fatty liver disease (NAFLD). These work provide theoretical evidence for the development of PTIB001 related agents for NAFLD.