Clinical nutrition support treatment on children with hand foot and mouth disease

doi:10.3877/cma.j.issn.1674-1358.2018.03.017

Abstract

Abstract:

Objective

To investigate the effect of nutritional support treatment on blood trace elements, immunoglobulin content and clinical situation of children with hand, foot and mouth disease (HFMD).

Methods

Total of 100 hospitalized children with confirmed HFMD (including primary infection and repeated infection) in the Third Hospital of Qinhuangdao from May 2015 to October 2016 were divided into treatment group and control group, randomly, with 50 cases in each group. The nutritional support treatment group according to the age and course of disease were given individualized, while the control group were only given routine treatment. The changes of the blood trace elements and immunoglobulin contents were compared.

Results

The levels of serum Zn (4.83 ± 1.57 μg/ml) and Ca (66.73 ± 10.48 μg/ml) of cases in treatment group after treatment were higher than those in control group, with significant differences (t = 3.760, P = 0.031; t = 2.790, P = 0.030). The levels of serum IgA (1.99 ± 0.31 mg/dl) and IgG (13.74 ± 2.86 mg/dl) of cases in treatment group after treatment were higher than those in control group, with significant differences (t = 2.590, P = 0.001; t = 2.650, P = 0.025). The imbalance of trace elements in blood and immunoglobulin levels of cases in treatment group after treatment were significantly improved compared with those of the control group. The fever and hospitalization period of cases in treatment group were significantly shorter than those of the control group (t = 15.512, P = 0.036; t = 10.202, P = 0.001).

Conclusions

Timely and effective nutritional support could improve the immunity and clinical outcome of children.

Key words: Hand, foot and mouth disease, Nutritional intervention, Immunity

Hua Fu, Yanjing Li, Jianxia Xing, Yanling Ma, Bo Wen. Clinical nutrition support treatment on children with hand foot and mouth disease[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(03): 288-291.

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References 25

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组别	例数	治疗前			治疗后
组别	例数	锌	铁	钙	锌	铁	钙
治疗组	50	3.64 ± 1.05	390.40 ± 65.27	57.89 ± 6.21	4.83 ± 1.57	391.41 ± 52.33	66.73 ± 10.48
对照组	50	3.64 ± 1.05	391.31 ± 62.26	57.17 ± 4.62	3.92 ± 2.14	392.14 ± 60.55	59.31 ± 7.16
t值		0.000	－0.450	0.700	3.760	－1.000	2.790
P值		0.080	1.123	0.097	0.031	2.365	0.030

组别	例数	治疗前			治疗后
组别	例数	锌	铁	钙	锌	铁	钙
治疗组	50	3.64 ± 1.05	390.40 ± 65.27	57.89 ± 6.21	4.83 ± 1.57	391.41 ± 52.33	66.73 ± 10.48
对照组	50	3.64 ± 1.05	391.31 ± 62.26	57.17 ± 4.62	3.92 ± 2.14	392.14 ± 60.55	59.31 ± 7.16
t值		0.000	－0.450	0.700	3.760	－1.000	2.790
P值		0.080	1.123	0.097	0.031	2.365	0.030

组别	例数	治疗前			治疗后
组别	例数	IgA	IgG	IgM	IgA	IgG	IgM
治疗组	50	1.11 ± 0.54	10.88 ± 2.39	1.46 ± 0.55	1.99 ± 0.31	13.74 ± 2.86	1.49 ± 0.82
对照组	50	1.09 ± 0.67	10.35 ± 2.71	1.45 ± 0.23	1.25 ± 0.49	10.94 ± 3.52	1.49 ± 0.35
t值		0.120	0.500	1.170	2.590	2.650	0.000
P值		1.023	0.667	0.797	0.001	0.025	3.561

组别	例数	治疗前			治疗后
组别	例数	IgA	IgG	IgM	IgA	IgG	IgM
治疗组	50	1.11 ± 0.54	10.88 ± 2.39	1.46 ± 0.55	1.99 ± 0.31	13.74 ± 2.86	1.49 ± 0.82
对照组	50	1.09 ± 0.67	10.35 ± 2.71	1.45 ± 0.23	1.25 ± 0.49	10.94 ± 3.52	1.49 ± 0.35
t值		0.120	0.500	1.170	2.590	2.650	0.000
P值		1.023	0.667	0.797	0.001	0.025	3.561

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