To investigate the current situation of unpaid blood donors with HIV infection in Baise, Guangxi Zhuang Autonomous Region from 2007 to 2014; and to provide security decisions for blood collection institutions and relevant departments.

Unpaid blood donors with HIV infection were selected from Baise City Blood Bank from 2007 to 2014. Routine HIV screening was applied to record blood samples.

There were 198 308 donor blood samples, among which, 253 samples were with anti-HIV positive. After confirmed by HIV Validation Laboratory of Baise Disease and Prevention and Control Center (CDC), 76 samples were confirmed anti-HIV positive and the HIV infection rate was about 0.04%. Compared with the confirmed cases, the cases of screening for anti-HIV positive was with significant difference (χ² = 95.306, P < 0.001). The confirmed cases with anti-HIV positive between men and women was with significant difference (χ²= 17.7895, P < 0.001).

There was a high rate of HIV infection among unpaid blood donors. The blood center should shorten the "window period" and improve the detection sensitivity. So the risk of transfusion-transmitted HIV was reduced and safeguard of clinical blood transfusion was ensured.