To investigate the nursing of acquired immunodeficiency syndrome (AIDS) complicated with fundus lesions during check scheme and the measures of occupational protection.

Comprehensive ophthalmic testing and CD4⁺ T lymphocytes detection were taken in 32 cases with AIDS with fundus lesions.

Among the 32 cases, 15 cases were with fundus changed, with the detectioned rate of 46.9%. Seven cases with eye shadow in the sight and blurred vision; 8 cases with no ocular symptoms; 10 cases with cotton-wool spot in fundus, 4 cases with pure retinal hemorrhage; 17 cases with normal fundus; 1 case with cytomegalovirus retinitis, accounting for 3% of AIDS patients complicated with fundus lesions.

AIDS patients could be diagnosed by clinical manifestation and fundus examination, who could be found fundus lesions early. Active treatment can prevent blindness, and effectively improve the patients quality of life.