Research progress on the correlation and mechanism of gastric microbiota and occurrence and development of gastric cancer

doi:10.3877/cma.j.issn.1674-1358.2025.05.002

Abstract

Abstract:

Gastric cancer is one of the most common malignant tumors worldwide, and its pathogenesis is complex, including genetic, environmental and dietary factors. In recent years, the relationship between gastric microbiota and gastric cancer has gradually become a hot research topic. More and more studies have shown that gastric microbiota plays an important role in the occurrence and development of gastric cancer. This review systematically expounds the relationship between the composition and changes of gastric microbiota and the occurrence and development of gastric cancer, including the association between microbial infections such as Helicobacter pylori, non-Helicobacter pylori bacteria, fungi and viruses and gastric cancer, as well as the influence and mechanism of microbial imbalance on gastric cancer. At the same time, the limitations of existing research and future research directions are also discussed, which provides new ideas and strategies for the prevention and treatment strategies of gastric cancer.

Key words: Gastric cancer, Gastric microbiota, Dysregulation of microbiota

Xiaobin Fan, Yingshu Lyu, Ruijuan Zhang, Wenxing Li, Yanjun Lian. Research progress on the correlation and mechanism of gastric microbiota and occurrence and development of gastric cancer[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2025, 19(05): 265-270.

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