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Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (06): 321-326. doi: 10.3877/cma.j.issn.1674-1358.2024.06.001

• Review •     Next Articles

Application of thalidomide and its derivatives in human immunodeficiency virus infection-related diseases

Ling Ren1, Hongxia Dan1,()   

  1. 1.State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-08-28 Online:2024-12-15 Published:2025-03-06
  • Contact: Hongxia Dan

Abstract:

Patients infected with human immunodeficiency virus (HIV) are susceptible to various opportunistic infections and tumors.These diseases often have complex clinical and pathological manifestations, poor prognosis and are difficult to manage.Thalidomide and its derivatives have a wide range of pharmacological effects including antiinflammatory, immunomodulatory and anti-tumor activities.In recent years, thalidomide and its derivatives have been increasingly used in HIV infection-related diseases, mainly including mucosal ulcer, prurigo nodosa, opportunistic infection, immune reconstruction inflammatory syndrome, Kaposi sarcoma, non-Hodgkin lymphoma and Castleman disease.This paper mainly reviews the application of thalidomide and its derivatives in the above diseases.

Key words: Human immunodeficiency virus, Acquired immune deficiency syndrome, Thalidomide, Immunomodulatory imide drugs

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