Clinical characteristics of dry eye in patients with chronic hepatitis C

doi:10.3877/cma.j.issn.1674-1358.2023.01.008

Abstract

Abstract:

Objective

To investigate the prevalence of dry eye in patients with chronic hepatitis C (CHC).

Methods

Total of 69 patients (138 eyes) with CHC, who were 23 to 75 years old, with the average of (45.39 ± 12.88) years old, diagnosed in Department of Hepatology of Beijing Ditan Hospital, Capital Medical University from February 2021 to January 2022 were collected. Medical history, levels of platelet count (PLT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the patients were collected and the AST/PLT ratio index (APRI) was calculated. All patients received the international standard ocular surface disease index (OSDI) dry eye questionnaire, and the observation indexes included Schirmer Ⅰ test, noninvasive breakup time average (NIBUT_av), tear meniscus height (TMH). According to the OSDI score, patients with 0-12 score were divided into asymptomatic group (36 cases), and with the score ≥ 13 were considered as symptomatic group (33 cases). Statistical treatment was performed by independent sample t-test, rank combination test and Pearson χ² test according data type.

Results

Schirmer Ⅰ of patients in asymptomatic group was 12.5 (8.25, 17.75) mm/5 min, NIBUT_av was 12.1 (6.35, 20.65) s, TMH was 0.26 (0.19, 0.34) mm; For patients in symptomatic group, Schirmer Ⅰwas 11 (6, 19.25) mm/5 min, NIBUT_av was 7.95 (4.78, 13.32) s, TMH was 0.24 (0.20, 0.28) mm. Total of 27 cases were diagnosed as dry eyes, with abnormal results of NIBUT as the main manifestation. There was significant difference in NIBUT between the two groups (Z = -3.77, P < 0.01). But there were no significant difference in Schirmer Ⅰ (Z =-1.15, P = 0.25) and TMH (Z =-0.96, P = 0.34). The course of hepatitis C virus (HCV) infection was 7 (3.25, 12) years in asymptomatic group and 11 (7, 16) years in symptomatic group, with significant difference (Z =-2.40, P = 0.02). ALT levels of patients in asymptomatic group and symptomatic groups were 79 (45.75, 128.75) U/L and 77.00 (42.5, 117.5) U/L, respectively, with significant difference (Z =-0.14, P = 0.89). APRI of patients in asymptomatic group and symptomatic groups were 0.62 (0.34, 0.88) and 0.78 (0.61, 1.03), with significant difference (Z = -0.20, P = 0.04).

Conclusions

The incidence rate of dry eye is high in CHC patients. CHC patients should be regularly examined for dry eye to improve their ocular surface status.

Key words: Chronic hepatitis C, Dry eye, Clinical characteristics

Shengnan Wang, Huiyu Sun, Ying Jie, Wen Xie, Feifei Mao, Dan Li, Dan Lu, Xiyao Liu. Clinical characteristics of dry eye in patients with chronic hepatitis C[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2023, 17(01): 48-54.

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References 37

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组别	例数	性别（例，男/女）	年龄（ ± s，岁）	OSDI得分[M（P25，P75）]
无症状组	36	23/13	47.17 ± 12.77	4.17（0.52，8.33）
有症状组	33	19/14	43.45 ± 12.92	22.92（16.67，39.59）
统计量		χ² = 0.29^a	t = 1.20	Z =－7.15
P值		0.59	0.24	< 0.001

组别	例数	性别（例，男/女）	年龄（ ± s，岁）	OSDI得分[M（P25，P75）]
无症状组	36	23/13	47.17 ± 12.77	4.17（0.52，8.33）
有症状组	33	19/14	43.45 ± 12.92	22.92（16.67，39.59）
统计量		χ² = 0.29^a	t = 1.20	Z =－7.15
P值		0.59	0.24	< 0.001

组别	病程（年）	ALT（U/L）	APRI
无症状组	7（3.25，12）	79（45.75，128.75）	0.62（0.34，0.88）
有症状组	11（7，16）	77（42.5，117.5）	0.78（0.61，1.03）
Z值	－2.40	－0.14	－2.01
P值	0.02	0.89	0.04

组别	病程（年）	ALT（U/L）	APRI
无症状组	7（3.25，12）	79（45.75，128.75）	0.62（0.34，0.88）
有症状组	11（7，16）	77（42.5，117.5）	0.78（0.61，1.03）
Z值	－2.40	－0.14	－2.01
P值	0.02	0.89	0.04

组别	例数	干眼检查阳性例数[例（%）]	干眼检查阳性眼数[只（%）]
无症状组	36	22（61.11）	35 （48.61）
有症状组	33	27（81.81）	48（72.72）
χ²值		14.77	13.36
P值		0.002	0.004

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