Five cases report of chronic liver disease with endogenous endophthalmitis and literature review

doi:10.3877/cma.j.issn.1674-1358.2021.02.012

Abstract

Abstract:

Objective

To improve the clinicians’ understanding, diagnostic and therapeutic levels of chronic liver diseases with endogenous endophthalmitis.

Methods

Total of 5 cases of chronic liver diseases with endogenous endophthalmitis admitted to Beijing Ditan Hospital, Capital Medical University from January 2009 to January 2020 were reported. Their diagnosis and treatment were summarized with literature review.

Results

All 5 patients were admitted to our hospital as chronic liver diseases with endogenous endophthalmitis, including 3 females and 2 males, aged from 49 to 80 years old. Two of them were endogenous fungal endophthalmitis, caused by Aspergillus fumigatus and Candida albicans; the other 3 were endogenous bacterial endophthalmitis, caused by Klebsiella pneumoniae, Streptococcus pneumoniae, and mixed infection of Klebsiella pneumoniae and Staphylococcus aureus, respectively. They all received systemic anti-infective therapy, and some of them were even treated with intravitreal injection and vitrectomy. However, the diseased eyes were all blind.

Conclusions

Chronic liver disease with endogenous endophthalmitis was a rare disease with poor prognosis. Endophthalmitis could cause destructive damage to eye tissue. Early diagnosis and treatment are extremely important.

Key words: Chronic liver disease, Endogenous endophthalmitis, Diagnosis, Treatment

Wei Li, Ying Duan, Liwei Zhuang, Huichun Xing. Five cases report of chronic liver disease with endogenous endophthalmitis and literature review[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2021, 15(02): 138-143.

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References 26

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病例编号	性别	年龄（岁）	患眼	致病微生物	检测方法	治疗方法	患眼预后	危险因素
1	女	50	右	烟曲霉菌	基因芯片	全身治疗+玻璃体腔注射+玻璃体切割术	失明	慢加亚急性肝功能衰竭（乙型肝炎） +糖皮质激素用药史
2	男	80	左	肺炎克雷伯菌肺炎亚种	血培养	全身治疗	失明	原发性胆汁性肝硬化
3	女	49	左	白色念珠菌	基因芯片	全身治疗+玻璃体腔注射	失明	慢加亚急性肝功能衰竭（乙型肝炎） +糖皮质激素用药史
4	女	58	左	肺炎克雷伯菌+金黄色葡萄球菌	分泌物培养+基因芯片	全身治疗	失明	失代偿期乙型肝炎肝硬化
5	男	49	左	咽峡炎链球菌	基因芯片	全身治疗+玻璃体切割术	失明	失代偿期丙型肝炎肝硬化+酒精性肝硬化+ 2型糖尿病

病例编号	性别	年龄（岁）	患眼	致病微生物	检测方法	治疗方法	患眼预后	危险因素
1	女	50	右	烟曲霉菌	基因芯片	全身治疗+玻璃体腔注射+玻璃体切割术	失明	慢加亚急性肝功能衰竭（乙型肝炎） +糖皮质激素用药史
2	男	80	左	肺炎克雷伯菌肺炎亚种	血培养	全身治疗	失明	原发性胆汁性肝硬化
3	女	49	左	白色念珠菌	基因芯片	全身治疗+玻璃体腔注射	失明	慢加亚急性肝功能衰竭（乙型肝炎） +糖皮质激素用药史
4	女	58	左	肺炎克雷伯菌+金黄色葡萄球菌	分泌物培养+基因芯片	全身治疗	失明	失代偿期乙型肝炎肝硬化
5	男	49	左	咽峡炎链球菌	基因芯片	全身治疗+玻璃体切割术	失明	失代偿期丙型肝炎肝硬化+酒精性肝硬化+ 2型糖尿病

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