Risk factors of asymptomatic infection of 307 patients with herpes simplex virus-2 IgG positive

doi:10.3877/cma.j.issn.1674-1358.2020.06.007

Abstract

Abstract:

Objective

To investigate the risk factors for asymptomatic infection of genital herpes.

Methods

Total of 307 patients with herpes simplex virus (HSV)-2 IgG positive were collected in Department of Dermatology of Beijing Ditan Hospital, Capital Medical University from August 2017 to August 2018, the clinical data were analyzed, retrospectively, excluding cases with HIV infection. Data of age, sex, complicated with other sexually transmitted diseases (STD) and HSV-1 IgG-positive were collected for statistical analysis, and the risk factors of asymptomatic infection with HSV-2 IgG positive were analyzed by multivariate Logistic regression analysis.

Results

The patients consisted of 164 males and 143 females, 199 genital herpes and 108 asymptomatic infections. There were 228 cases with HSV-1 IgG positive and 73 cases complicated with other STD. Age was not the risk factor to incidence of asymptomatic infection in cases with HSV-2 IgG positive (OR = 0.987, P = 0.258), but other STD (OR = 1.885, P = 0.020), female (OR = 1.747, P = 0.021) and HSV-1 IgG antibody positive (OR = 1.854, P = 0.035) were the risk factors of asymptomatic infection.

Conclusions

Coinfection of STD, female patients and HSV-1 IgG-positive were risk factors for asymptomatic infection of HSV-2, so attention should be paid to the detection of above indexes.

Key words: Herpes simplex virus-2, Asymptomatic infection, Risk factors, Logistic regression analysis

Chunbo Wei, Gang Wan, Hong Li, Guangxia Bai, Xin Wang, Dongling Wu, Tianwei Zhao, Xingyun Zhao, Liufeng Yuan, Yan Wu, Wenhui Lun. Risk factors of asymptomatic infection of 307 patients with herpes simplex virus-2 IgG positive[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2020, 14(06): 480-484.

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References 27

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一般资料		数值
平均年龄[M（P25，P75），岁]		36（30，43）
年龄分布[例（%）]
	18～20岁	18（2.3）
	21～30岁	85（27.7）
	31～40岁	116（37.8）
	41～50岁	64（20.8）
	> 51岁	55（11.4）
性别
	男	164（53.4）
	女	143（46.6）
症状
	生殖器疱疹组	199（64.8）
	无症状感染组	108（35.2）
HSV-1 IgG阳性率
	生殖器疱疹组	140（70.4）
	无症状感染组	88（81.5）
合并其他STD感染率
	生殖器疱疹组	39（19.6）
	无症状感染组	34（31.5）

一般资料		数值
平均年龄[M（P25，P75），岁]		36（30，43）
年龄分布[例（%）]
	18～20岁	18（2.3）
	21～30岁	85（27.7）
	31～40岁	116（37.8）
	41～50岁	64（20.8）
	> 51岁	55（11.4）
性别
	男	164（53.4）
	女	143（46.6）
症状
	生殖器疱疹组	199（64.8）
	无症状感染组	108（35.2）
HSV-1 IgG阳性率
	生殖器疱疹组	140（70.4）
	无症状感染组	88（81.5）
合并其他STD感染率
	生殖器疱疹组	39（19.6）
	无症状感染组	34（31.5）

组别	例数	年龄（岁）	性别[例（%）]		HSV-1 IgG [例（%）]		合并其他STD [例（%）]
组别	例数	年龄（岁）	男	女	阳性	阴性	是	否
生殖器疱疹组	199	36（30，43）	116（58.3）	83（41.7）	140（70.4）	59（29.6）	39（19.6）	160（80.4）
无症状感染组	108	34（29，43）	48（44.4）	60（55.6）	88（81.5）	20（18.5）	34（31.5）	74（68.5）
统计量		Z = 1.285	χ² = 5.394		χ² = 4.538		χ² = 5.455
P值		0.258	0.020		0.033		0.020

组别	例数	年龄（岁）	性别[例（%）]		HSV-1 IgG [例（%）]		合并其他STD [例（%）]
组别	例数	年龄（岁）	男	女	阳性	阴性	是	否
生殖器疱疹组	199	36（30，43）	116（58.3）	83（41.7）	140（70.4）	59（29.6）	39（19.6）	160（80.4）
无症状感染组	108	34（29，43）	48（44.4）	60（55.6）	88（81.5）	20（18.5）	34（31.5）	74（68.5）
统计量		Z = 1.285	χ² = 5.394		χ² = 4.538		χ² = 5.455
P值		0.258	0.020		0.033		0.020

影响因素	β值	Waldχ²值	P值	OR值	95%CI
合并其他STD	0.634	5.371	0.020	1.885	1.103～3.222
HSV-1 IgG	0.617	4.462	0.035	1.854	1.046～3.289
性别	0.558	5.351	0.021	1.747	1.089～2.803
年龄	-0.013	1.281	0.258	0.987	0.965～1.010

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