Correlation between CD64 index, neutrophil to lymphocyte ratio level and serum MP-IgM antibody titer in children with Mycoplasma pneumoniae pneumonia

doi:10.3877/cma.j.issn.1674-1358.2020.04.009

Abstract

Abstract:

Objective

To investigate the correlation between peripheral blood neutrophil CD64 index, neutrophil to lymphocyte ratio (NLR) levels and serum Mycoplasmsa pneamoniae-immunoglobulin M (MP-IgM) antibody titer in children with pneumonia mycoplasma pneumonia (MPP).

Methods

Total of 146 children with MPP diagnosed in Wuhan Dongxihu District People’s Hospital from February 2017 to May 2019 were enrolled. According to the severity of disease, there were 85 cases in mild group and 61 cases in severe group. According to the serum MP-IgM antibody titer, 48 cases were in low titer group (MP-IgM 1︰80), 51 cases in medium titer group (MP-IgM 1︰160, 1︰320) and 47 cases in high titer group (MP-IgM ≥ 1︰640). The levels of neutrophil CD64 index, NLR and serum antibody titer were compared among different disease severity groups, while CD64 index and NLR level in different serum MP IgM antibody titer groups were compared, respectively. Pearson correlation was used to analyze the correlation between CD64 index, NLR level and serum antibody titer.

Results

CD64 index, NLR, serum MP-IgM antibody titer level in severe group [(8.2 ± 1.7), (5.8 ± 1.2), serum MP-IgM antibody titer: 12 cases (19.7%) with 1︰80, 13 cases (21.3%) with 1︰160, 36 cases (59.0%) ≥ 1︰320] higher than those of the mild group [(5.3 ± 1.1), (4.1 ± 0.6), serum MP-IgM antibody titer: 36 cases (42.3%) with 1︰80, 26 cases (30.6%) with 1︰160, 23 cases (27.1%) ≥ 1︰320], all with significant differences (t = 11.633, 10.576, χ² = 15.676; all P < 0.001). The CD64 index and NLR levels of cases in high titer group were (8.03 ± 1.69) and (5.94 ± 1.35), significantly higher than those of the medium titer group [(6.42 ± 1.53) and (4.68 ± 0.87)] and the low titer group [(5.26 ± 1.08) and (4.02 ± 0.72)], with significant differences (F = 43.321, 44.226; both P < 0.001). The CD64 index and NLR level of cases in medium titer group were higher than those of cases in low titer group, with significant differences (t = 4.653, 3.961; both P < 0.001). Pearson correlation analysis showed that CD64 index and NLR level were positively correlated with serum MP-IgM antibody titer (r = 0.611, 0.608; both P < 0.001).

Conclusions

CD64 index and NLR were positively correlated with serum MP-IgM antibody titer. As the condition of MPP was aggravated, the levels of three indicators increased. Therefore, simultaneous detection of three indicators could be helpful to early diagnosis of the condition of children with MPP and adjust the treatment plan in time.

Key words: Mycoplasma pneumoniae pneumonia, Neutrophil CD64 index, Neutrophil to lymphocyte ratio, Serum antibody titer

Haiyan Guan, Biao Gao. Correlation between CD64 index, neutrophil to lymphocyte ratio level and serum MP-IgM antibody titer in children with Mycoplasma pneumoniae pneumonia[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2020, 14(04): 315-320.

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References 25

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组别	例数	性别[例（%）]		年龄（ ± s，岁）	病程（ ± s，d）
组别	例数	男	女	年龄（ ± s，岁）	病程（ ± s，d）
轻症组	85	47（55.3）	38（44.7）	6.1 ± 1.3	5.4 ± 0.9
重症组	61	32（52.5）	29（47.5）	6.0 ± 1.2	5.7 ± 1.0
统计量	?	χ² = 0.115		t = 0.596	t = 1.622
P值	?	0.735		0.552	0.107

组别	例数	性别[例（%）]		年龄（ ± s，岁）	病程（ ± s，d）
组别	例数	男	女	年龄（ ± s，岁）	病程（ ± s，d）
轻症组	85	47（55.3）	38（44.7）	6.1 ± 1.3	5.4 ± 0.9
重症组	61	32（52.5）	29（47.5）	6.0 ± 1.2	5.7 ± 1.0
统计量	?	χ² = 0.115		t = 0.596	t = 1.622
P值	?	0.735		0.552	0.107

组别	例数	性别[例（%）]		年龄（ ± s，岁）	病程（ ± s，d）
组别	例数	男	女	年龄（ ± s，岁）	病程（ ± s，d）
低滴度组	48	25（52.1）	23（47.9）	6.2 ± 1.4	5.4 ± 0.8
中滴度组	51	28（54.9）	23（45.1）	6.1 ± 1.3	5.5 ± 0.9
高滴度组	47	26（55.3）	21（44.7）	5.9 ± 1.2	5.8 ± 1.0
统计量	?	χ² = 0.120		F = 0.586	F = 2.006
P值	?	0.729		0.558	0.138

组别	例数	性别[例（%）]		年龄（ ± s，岁）	病程（ ± s，d）
组别	例数	男	女	年龄（ ± s，岁）	病程（ ± s，d）
低滴度组	48	25（52.1）	23（47.9）	6.2 ± 1.4	5.4 ± 0.8
中滴度组	51	28（54.9）	23（45.1）	6.1 ± 1.3	5.5 ± 0.9
高滴度组	47	26（55.3）	21（44.7）	5.9 ± 1.2	5.8 ± 1.0
统计量	?	χ² = 0.120		F = 0.586	F = 2.006
P值	?	0.729		0.558	0.138

组别	例数	CD64指数（ ± s）	NLR（ ± s）	血清MP-IgM抗体滴度[例（%）]
组别	例数	CD64指数（ ± s）	NLR（ ± s）	1︰80	1︰160	≥ 1︰320
轻症组	85	5.3 ± 1.1	4.1 ± 0.6	36（42.3）	26（30.6）	23（27.1）
重症组	61	8.2 ± 1.7	5.8 ± 1.2	12（19.7）	13（21.3）	36（59.0）
统计量	?	t = 1.633	t = 10.576	χ² = 15.676
P值	?	< 0.001	< 0.001	< 0.001

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