To investigate the efficacy of vancomycin compound antibiotic bone cement implantation on treatment of postoperative orthopedic infection.

Total of 22 patients with postoperative infection in Orthopedics Department of Luohu District People’s Hospital in Shenzhen City from January 2016 to December 2017 were seleced. All of them were treated with the vancomycin compound antibiotic bone cement implantation, and the efficacy was evaluated.

The pathogenic bacteria were cultured from the inflammatory tissue and granulation of 20 patients, among which 40% (8/20) were methicillin-resistant Staphylococcus aureus (MRSA), 30% (6/20) were Staphylococcus epidermidis, 15% (3/20) were Klebsiella pneumoniae, 10% (2/20) were Pseudomonas aeruginosa and 5% (1/20) was Staphylococcus capillaries. The interval between the first operation of 22 patients and the implantation of vancomycin compound antimicrobial bone cement beads was 16-750 d, while the retention time of the beads in vivo was 44-422 d. All patients were followed up for 4-15 months after vancomycin compound antibiotic bone cement implantation, among whom, 21 cases (95.45%) were with infection controlled, 21 cases (95.45%) were cured, 1 case (4.55%) was not with infection controlled, and the infection control rate and cure rate were both 95.45% (21/22).

Vancomycin compound antibiotic bone cement implantation is effective in treatment of orthopaedic infection, it could be used as the first choice for the treatment of orthopedic postoperative infection.