Correlation between intrauterine infection and lung injury of premature infants

doi:10.3877/cma.j.issn.1674-1358.2020.02.008

Abstract

Abstract:

Objective

To investigate the correlation between intrauterine infection and lung injury of premature infants.

Methods

The clinical data of 579 premature infants who were admitted to Maternal and Child Health Hospital in Guangxi Zhuang Autonomous Region from January 2017 to January 2019 were analyzed, retrospectively. Among them, 72 cases were with lung injury and 507 cases without lung injury. According to presence or absence of maternal intrauterine infection during pregnancy period, they were divided into intrauterine infection group (256 cases) and non-intrauterine infection group (323 cases). The correlation between intrauterine infection and lung injury in premature infants was analyzed by Pearson correlation analysis.

Results

The incidence rates of transient hyperpnea in premature infants, neonatal pneumonia and neonatal respiratory distress syndrome of intrauterine infection group were significantly higher than those of non-intrauterine infection group [7.42% (19/256), 9.38% (24/256), 2.73% (7/256) vs. 3.13% (8/323), 4.68% (12/323), 0.78% (2/323)], with significant differences (χ² = 7.866, 7.854, 4.187, all P < 0.001). Among the 72 premature infants with lung injury, Murray lung injury score in intrauterine infection group was higher than that of non-intrauterine infection group [(2.76 ± 0.83) vs. (2.04 ± 0.66)], with significant difference (t = 3.595, P < 0.001). The levels of maternal inflammatory factors, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in intrauterine infection group were higher than those of non-intrauterine infection group , with significant differences (t = 4.663, 3.529; all P < 0.001). Murray lung injury score was divided according to 0.45 point as a stage. As Murray lung injury score increasing, the incidence of intrauterine infection increased, with significant differences (χ² = 25.402, P < 0.001). Pearson correlation analysis showed that intrauterine infection inflammatory factors (IL-6 and TNF-α) were positively correlated with Murray lung injury score, with significant differences (r = 0.821, 0.833; all P < 0.001).

Conclusions

Intrauterine infection could result the increased incidence of lung injury in premature infants. The levels of maternal inflammatory factors were associated with Murray lung injury scores in the premature infants.

Key words: Intrauterine infection, Premature infant, Lung injury, Correlation

Lingxiao Li, Dan Zhao, Yan Mo. Correlation between intrauterine infection and lung injury of premature infants[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2020, 14(02): 128-132.

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Figures/Tables 6

References 25

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临床资料		宫内感染组（256例）	非宫内感染组（323例）	统计量	P值
胎龄（±s，周）		32.16 ± 0.94	32.21 ± 0.75	t = 0.712	0.477
体重（±s，g）		2 096.94 ± 108.73	2 106.87 ± 114.25	t = 1.061	0.289
胎心变化[例（%）]		?	?	χ² = 0.985	0.322
?	有	45 （ 17.58 ）	47 （ 14.55 ）	?	?
?	无	211（82.42）	276（85.45）	?	?
1 min Apgar评分[例（%）]		?	?	χ² = 0.054	0.829
?	≤ 7分	59 （ 23.05 ）	72 （ 22.29 ）	?	?
?	> 7分	197（76.95）	251（77.71）	?	?
羊水[例（%）]		?	?	χ² = 4.358	0.223
?	正常	187 （ 73.05 ）	234 （ 72.46 ）	?	?
?	Ⅰ度污染	13（5.08）	7（2.17）
?	Ⅱ度污染	15（16.02）	20（6.19）
?	Ⅲ度污染	41（19.53）	62（19.20）
肺损伤[例（%）]		?	?	χ² = 21.224	< 0.001
?	是	50 （ 19.53 ）	22 （ 6.81 ）	?	?
?	否	251（98.05）	301（93.19）	?	?

临床资料		宫内感染组（256例）	非宫内感染组（323例）	统计量	P值
胎龄（±s，周）		32.16 ± 0.94	32.21 ± 0.75	t = 0.712	0.477
体重（±s，g）		2 096.94 ± 108.73	2 106.87 ± 114.25	t = 1.061	0.289
胎心变化[例（%）]		?	?	χ² = 0.985	0.322
?	有	45 （ 17.58 ）	47 （ 14.55 ）	?	?
?	无	211（82.42）	276（85.45）	?	?
1 min Apgar评分[例（%）]		?	?	χ² = 0.054	0.829
?	≤ 7分	59 （ 23.05 ）	72 （ 22.29 ）	?	?
?	> 7分	197（76.95）	251（77.71）	?	?
羊水[例（%）]		?	?	χ² = 4.358	0.223
?	正常	187 （ 73.05 ）	234 （ 72.46 ）	?	?
?	Ⅰ度污染	13（5.08）	7（2.17）
?	Ⅱ度污染	15（16.02）	20（6.19）
?	Ⅲ度污染	41（19.53）	62（19.20）
肺损伤[例（%）]		?	?	χ² = 21.224	< 0.001
?	是	50 （ 19.53 ）	22 （ 6.81 ）	?	?
?	否	251（98.05）	301（93.19）	?	?

组别	例数	暂时性呼吸过快	新生儿肺炎	新生儿呼吸窘迫综合征
宫内感染组	256	19（7.42）	24（9.38）	7（2.73）
非宫内感染组	323	8（3.13）	12（4.68）	2（0.78）
χ²值	?	7.866	7.854	4.187
P值	?	< 0.001	< 0.001	0.041

组别	例数	暂时性呼吸过快	新生儿肺炎	新生儿呼吸窘迫综合征
宫内感染组	256	19（7.42）	24（9.38）	7（2.73）
非宫内感染组	323	8（3.13）	12（4.68）	2（0.78）
χ²值	?	7.866	7.854	4.187
P值	?	< 0.001	< 0.001	0.041

组别	例数	早产儿		产妇宫内分泌物炎性因子
组别	例数	肺损伤[例（%）]	Murray肺损伤评分（±s，分）	IL-6（±s，μg/L）	TNF-α（±s，μg/L）
宫内感染组	256	50（19.53）	2.76 ± 0.83	105.87 ± 20.35	6.13 ± 1.15
非宫内感染组	323	22（6.81）	2.04 ± 0.66	82.54 ± 17.57	5.14 ± 0.96
统计量	?	χ² = 21.224	t = 3.595	t = 4.663	t = 3.529
P值	?	< 0.001	< 0.001	< 0.001	< 0.001

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