Analysis on polymorphic erythematous drug eruption during treatment of children with mycoplasma pneumoniae infection

doi:10.3877/cma.j.issn.1674-1358.2019.06.008

Abstract

Abstract:

Objective

To investigate the clinical characteristics and laboratory indexes of polymorphic erythematous drug eruption during the treatment of children with mycoplasma pneumoniae infection.

Methods

The clinical data of 120 children with polymorphic erythematous drug eruption during the treatment of mycoplasma pneumoniae infection in Longhua District Central Hospital, Shenzhen from March 2014 to March 2018 were collected. The clinical symptoms and signs were analyzed. Data of blood routine, electrocardiogram, renal function and myocardial enzyme were analyzed, retrospectively. Patients were given anti-inflammatory treatment for mycoplasma infection, and the efficacy and prognosis were observed.

Results

Among the 120 children with mycoplasma pneumoniae infection, all developed diffuse erythema and macular papules [120 (100.00%)], which were significantly higher than cases with mucosal involvement [117 (97.50%)] (χ² = 3.421, P = 0.046), fever [69 (57.50%)] (χ² = 64.762, P < 0.001), headache [107 (89.17%)] (χ² = 13.744, P < 0.001), joint pain [94 (78.33%)] (χ² = 29.159, P < 0.001) and muscle pain [88 (73.33%)] (χ² = 36.923, P < 0.001), all with significant differences. The laboratory results of 120 children with mycoplasma pneumoniae infection were as follows: cases with leukocyte elevated, neutrophil elevated, eosinophil elevated, alanine aminotransferase elevated, glutamate transpeptidase elevated, total protein elevated, albumin elevated, direct bilirubin elevated, cholinesterase elevated, uric acid elevated, creatinine elevated, urea nitrogen elevated, abnormal ECG and creatine kinase elevated were 63 cases (52.50%), 46 cases (38.33%), 12 cases (10.00%), 53 cases (44.17%), 17 cases (14.17%), 30 cases (25.00%), 7 cases (5.83%), 24 cases (20.00%), 9 cases (7.50%), 23 cases (19.17%), 18 cases (15.00%), 21 cases (17.50%), 10 cases (8.33%) and 11 cases (9.17%), respectively. The temperature of 69 children with fever returned to normal within 3-7 days, and the skin lesions of 120 children subsided obviously within 3-7 days, also the blisters dried up. The shortest course of treatment of 120 children was 7 days, the longest was 51 days, and the average was 17 days. One case died of multiple organ failure due to a serious basic disease.

Conclusions

For children infected with mycoplasma pneumoniae, the occurrence of polymorphic erythematous drug eruption should be prevented, and drug should be suspended immediately once abnormality occurred, and specific intervention of dexamethasone and other drugs should be administrated to effectively ensure the safety of medication.

Key words: Polymorphic erythematous drug eruption, Mycoplasma pneumoniae, Infection, Clinical manifestations, Laboratory index

Youming Hong, Jiajun Chang, Huichao Mo. Analysis on polymorphic erythematous drug eruption during treatment of children with mycoplasma pneumoniae infection[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2019, 13(06): 501-505.

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References 25

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症状、体征	例数	比例（%）
全身弥漫性红斑、斑丘疹	120	100.00
黏膜受累	117	97.50^a
发热	69	57.50^a
头痛	107	89.17^a
关节痛	94	78.33^a
肌肉酸痛	88	73.33^a

症状、体征	例数	比例（%）
全身弥漫性红斑、斑丘疹	120	100.00
黏膜受累	117	97.50^a
发热	69	57.50^a
头痛	107	89.17^a
关节痛	94	78.33^a
肌肉酸痛	88	73.33^a

实验室指标	例数	比例
白细胞升高	63	52.50
中性粒细胞升高	46	38.33^a
嗜酸性粒细胞升高	12	10.00^a
丙氨酸氨基转移酶升高	53	44.17^a
谷氨酰转肽酶升高	17	14.17^a
总蛋白升高	30	25.00^a
白蛋白升高	7	5.83^a
直接胆红素升高	24	20.00^a
胆碱酯酶升高	9	7.50^a
尿酸升高	23	19.17^a
肌酐升高	18	15.00^a
尿素氮升高	21	17.50^a
心电图异常	10	8.33^a
肌酸激酶升高	11	9.17^a

实验室指标	例数	比例
白细胞升高	63	52.50
中性粒细胞升高	46	38.33^a
嗜酸性粒细胞升高	12	10.00^a
丙氨酸氨基转移酶升高	53	44.17^a
谷氨酰转肽酶升高	17	14.17^a
总蛋白升高	30	25.00^a
白蛋白升高	7	5.83^a
直接胆红素升高	24	20.00^a
胆碱酯酶升高	9	7.50^a
尿酸升高	23	19.17^a
肌酐升高	18	15.00^a
尿素氮升高	21	17.50^a
心电图异常	10	8.33^a
肌酸激酶升高	11	9.17^a

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