To investigae the changes of VCS parameters of peripheral blood monocyte community in patients with newly diagnosed active pulmonary tuberculosis (APTB), retrospectively, and to explore the clinical value of APTB diagnosis.

Total of 83 patients with APTB diagnosed by The Sixth People’s Hospital of Nantong from October 2015 to January 2016 were selected as APTB group and 79 healthy persons examined in The First People’s Hospital of Nantong City from September to December 2015 were selected as control group. The peripheral blood routine indexes of APTB group and control group were detected by Coulter LH 750 blood analyzer, and the monocytes were recorded. The expression levels ofinterleukin-1β(IL-1β), IL-6 andtumor necrosis factor-α(TNF-α) were measured and compared between the two groups, and the correlation between VCS parameters and cytokine concentration was analyzed.

The mean volume (MMV) and mean volume distribution width (MDW) of peripheral blood monocytes in APTB group were significantly higher than those of the control group (t= 7.616,P< 0.001;t = 7.349,P < 0.001). There was a positive correlation between MMV and IL-1βexpression (r = 0.417,P < 0.001). The area under the ROC curve of MMV was 0.899, and when the critical value was 172.6 fl, the sensitivity and specificity of diagnosing APTB were 80.7% and 86.1%, respectively.

The VCS parameters of peripheral blood monocyte community in patients with APTB have been changed, MMV has been increased significantly, and some heterogeneity has been produced, which has certain diagnostic value for clinical auxiliary diagnosis of APTB.