Clinical characteristic of patients with syphilis and cerebral infarction complicated with and without atherosclerosis risk factors

doi:10.3877/cma.j.issn.1674-1358.2018.04.008

Abstract

Abstract:

Objective

To investigate the differences between patients with and without atherosclerosis risk factors of syphilis complicated with cerebral infarction.

Methods

Total of 24 patients of syphilis complicated with cerebral infarction were collected from April 3rd, 2015 to July 28th, 2017 in Beijing Ditan Hospital, Capital Medical University, and were devided into two groups: group with and without atherosclerosis risk factors (8 cases and 16 cases, respectively). The cerebrospinal fluid and CTA, record general information were detected, and the differences between the two groups were compared, respectively.

Results

Patients without atherosclerosis risk factors were younger (43.0 ± 8.7 years old) than cases with atherosclerosis risk factors (58.1 ± 15.2 years old) (t= 2.59,P= 0.016). The preponderance of men exists in both groups, the proportion of male cases was almost equal (62.5%and75.0% of cases without and with atherosclerosis risk factors, respectively), without significant difference (χ²= 0.40, P= 0.9). Intracranial arteries were mainly involved in cases without risk factors (75.0%vs. 31.3%;χ²= 4.11,P< 0.05). Rates of cerebral infarction history had no significant difference (12.5%vs. 50.0%;χ²= 3.2,P> 0.05). The percentage of neurosyphilis between two groups were not statistically significant (62.5%vs. 92.9%;χ²= 3.15,P> 0.05).

Conclusions

Patients of syphilis complicated with cerebral infarction without atherosclerosis risk factors were younger. Intracranial arteries were mainly involved in those patients.

Key words: Syphilis, Atherosclerosis, Cerebral infarction

Kaiyu Qin, Xiaoyang Ma, Wenqing Wu, Yuming Huang, Dongmei Xu. Clinical characteristic of patients with syphilis and cerebral infarction complicated with and without atherosclerosis risk factors[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(04): 354-359.

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Figures/Tables 3

References 23

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指标		无动脉粥样硬化危险因素组（8例）	有动脉粥样硬化危险因素组（16例）	统计量	P值
平均年龄（±s，岁）		43.0 ± 8.7	58.1 ± 15.2	t = 2.59	0.016
性别[例（%）]		?	?	χ²= 0.40	0.530
?	男	5（62.5）	12（75.0）	?	?
?	女	3（37.5）	4（25.0）	?	?
病变血管分布[例（%）]		8（100.0）	16（100.0）	χ²= 4.11	0.043
?	仅颅内血管	6（75.0）	5（31.3）	?	?
?	颈部血管病变或颈部和颅内血管均有病变	2（25.0）	11（68.8）	?	?
既往存在脑梗死病史[例（%）]		8（100.0）	16（100.0）	χ²= 3.20	0.074
?	有	1（12.5）	8（50.0）	?	?
?	无	7（87.5）	8（50.0）	?	?
符合神经梅毒标准[例（%）]		8（100.0）	16（100.0）	χ²= 3.15	0.076
?	符合	5（62.5）	13（81.3）	?	—
?	脑脊液指标不符合	3（37.5）	1（6.3）^a	—	—

指标		无动脉粥样硬化危险因素组（8例）	有动脉粥样硬化危险因素组（16例）	统计量	P值
平均年龄（±s，岁）		43.0 ± 8.7	58.1 ± 15.2	t = 2.59	0.016
性别[例（%）]		?	?	χ²= 0.40	0.530
?	男	5（62.5）	12（75.0）	?	?
?	女	3（37.5）	4（25.0）	?	?
病变血管分布[例（%）]		8（100.0）	16（100.0）	χ²= 4.11	0.043
?	仅颅内血管	6（75.0）	5（31.3）	?	?
?	颈部血管病变或颈部和颅内血管均有病变	2（25.0）	11（68.8）	?	?
既往存在脑梗死病史[例（%）]		8（100.0）	16（100.0）	χ²= 3.20	0.074
?	有	1（12.5）	8（50.0）	?	?
?	无	7（87.5）	8（50.0）	?	?
符合神经梅毒标准[例（%）]		8（100.0）	16（100.0）	χ²= 3.15	0.076
?	符合	5（62.5）	13（81.3）	?	—
?	脑脊液指标不符合	3（37.5）	1（6.3）^a	—	—

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