Changes and clinical significance of the inflammatory markers in patients with malaria

doi:10.3877/cma.j.issn.1674-1358.2018.03.008

Abstract

Abstract:

Objective

To evaluate the significance of markers of inflammation in the diagnosis of malaria.

Methods

Total of 118 patients with malaria, 124 patients with local bacterial infection and 64 patients with sepsis hospitalized in Beijing Ditan Hospital, Capital Medical University from November 2011 to March 2015 were collected. The general condition and laboratory results of infection of patients were analyzed, retrospectively. The differences of WBC, C-reactive protein and procalcitonin were compared between patients with local bacterial infection, sepsis and malaria, respectively.

Results

The levels of procalcitonin (χ² = 5.89, P < 0.001) in patients with malaria were significantly higher than that of patients with local infection, which was not significantly different compared with patients with malaria and sepsis (χ² =-0.93, P = 1.000). The level of C-reactive protein in patients with malaria was significantly higher than that of patients with sepsis (χ² = 5.32, P < 0.001) and patients with local infection (χ² = 7.85、P < 0.001), with significant differeces. The malaria patients with severe complications had significant higher procalcitonin levels than those without severe complication (Z =-3.04, P = 0.002).

Conclusions

Procalcitonin and C-reactive protein increased significantly in patients with malaria. The increased procalcitonin and C-reactive protein contributed to the differential diagnosis of malaria and unexplained infection.

Key words: Malaria, Procalcitonin, C-reactive, Infection, Differential diagnosis

Xuesong Gao, Jiang Guo, Xuefei Duan. Changes and clinical significance of the inflammatory markers in patients with malaria[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(03): 240-243.

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References 20

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组别	例数	WBC（× 10⁹/L）	CRP（mg/L）	PCT（ng/ml）
疟疾组	118	5.82（4.25，7.41）	99.00（46.89，169.61）	3.93（0.82，12.77）
局部感染组	124	6.35（4.16，9.58）	20.50（9.03，36.28）	0.69（0.35，1.29）
败血症组	64	6.96（4.98，11.27）	34.80（15.36，82.20）	4.94（1.17，21.16）
χ²值		13.18	66.81	47.82
P值		0.001	< 0.001	< 0.001

组别	例数	WBC（× 10⁹/L）	CRP（mg/L）	PCT（ng/ml）
疟疾组	118	5.82（4.25，7.41）	99.00（46.89，169.61）	3.93（0.82，12.77）
局部感染组	124	6.35（4.16，9.58）	20.50（9.03，36.28）	0.69（0.35，1.29）
败血症组	64	6.96（4.98，11.27）	34.80（15.36，82.20）	4.94（1.17，21.16）
χ²值		13.18	66.81	47.82
P值		0.001	< 0.001	< 0.001

组别	WBC（× 10⁹/L）	CRP（mg/L）	PCT（ng/ml）
普通疟疾组	5.83（4.27，7.42）	100.75（46.65，170.2）	3.72（0.80，11.61）
重症疟疾组	5.24（2.93，6.99）	90.90（49.95，185.80）	60.92（26.81，81.50）
χ²值	－1.12	－0.01	－3.040
P值	0.27	0.90	0.002

组别	WBC（× 10⁹/L）	CRP（mg/L）	PCT（ng/ml）
普通疟疾组	5.83（4.27，7.42）	100.75（46.65，170.2）	3.72（0.80，11.61）
重症疟疾组	5.24（2.93，6.99）	90.90（49.95，185.80）	60.92（26.81，81.50）
χ²值	－1.12	－0.01	－3.040
P值	0.27	0.90	0.002

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