Brucellosis is one of the most common zoonoses all over the world. In China, the incidence of human brucellosis has been rising continually, which brings a serious public health problem and socio-economic issue. Brucellosis can involve different systems, and can lead to relapse or chronicity if not treated timely and properly, and even a variety of complications which will seriously affect the prognosis of patients. So it is critical to diagnose and treat as early as impossible. This paper reviewed the current knowledge on etiology, epidemiology, clinical manifestations, laboratory diagnostics, different systemic complications and antibiotic therapy.