Identification, drug resistance and clinical infection analysis of Staphylococcus lugdunensis

doi:10.3877/cma.j.issn.1674-1358.2018.01.016

Abstract

Abstract:

Objective

To investigate the clinical distribution and the drug resistance of Staphylococcus lugdunensis.

Methods

Total of 34 strains from the 261^st Hospital of the People’s Liberation Army and Haidian Hospital of Beijng were collected. Staphylococcus lugdunensis were identified by VITEK-2 Compact and MALDI-TOF MS apply protein mass spectrometry. The drug resistance was analyzed by Gram-positive bacteria susceptibility test product VITEK-2 AST-GP67 Test Kit and WHONET 5.6 and the statistical analysis were performed by Fisher exact probabilities.

Results

Wound secretion due to skin and soft tissue infections, accounting for 47%; following by bone and joint infections, breast diseases and gynecological diseases, account for 9%, then following by bloodstream infections, ear problems, nose diseases and urinary system infections, account for 6%. The resistance of Staphylococcus lugdunensis to penicillin reached 91%, but it was sensitive to most other antibacterial medicines. Positive bacteria strains of Methicillin-resistant Staphylococcus lugdunensis account for 32%. There was no significant difference of the resistant rates to antibacterial drugs between patients in the positive group and negative group.

Conclusions

The infection sites of Staphylococcus lugdunensis were mainly in skin, tissues, breast bone, joint, none, ears and genitourinary region, and were sensitive to most of the clinical antibiotics.

Key words: Staphylococcus lugdunensis, Antibiotic, Resisitance

Wei Cui, Shushi Tian, Baie Feng, Jingrong Cao, Yannan Tan, Peiyan Huang, Chaojun Liu. Identification, drug resistance and clinical infection analysis of Staphylococcus lugdunensis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(01): 80-84.

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Figures/Tables 4

References 18

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标本种类	株数	构成比（%）
伤口分泌物	16	47
乳腺分泌物	3	9
关节液	3	9
宫颈分泌物	3	9
静脉血	2	6
耳分泌物	2	6
尿道分泌物	2	6
鼻分泌物	2	6
穿刺液	1	2
总数	34	100

标本种类	株数	构成比（%）
伤口分泌物	16	47
乳腺分泌物	3	9
关节液	3	9
宫颈分泌物	3	9
静脉血	2	6
耳分泌物	2	6
尿道分泌物	2	6
鼻分泌物	2	6
穿刺液	1	2
总数	34	100

抗菌药物	耐药	中介	敏感
青霉素	91	0	9
庆大霉素	6	0	94
左氧氟沙星	6	3	91
克林霉素	30	3	67
利奈唑胺	0	0	100
四环素	12	0	88
呋喃妥因	0	0	100
复方新诺明	12	0	88
苯唑西林	32	0	68
环丙沙星	6	9	85
莫西沙星	0	6	94
红霉素	26	4	70
喹努普汀/达福	0	0	100
万古霉素	0	0	100
替加环素	0	0	100
利福平	0	3	97

抗菌药物	耐药	中介	敏感
青霉素	91	0	9
庆大霉素	6	0	94
左氧氟沙星	6	3	91
克林霉素	30	3	67
利奈唑胺	0	0	100
四环素	12	0	88
呋喃妥因	0	0	100
复方新诺明	12	0	88
苯唑西林	32	0	68
环丙沙星	6	9	85
莫西沙星	0	6	94
红霉素	26	4	70
喹努普汀/达福	0	0	100
万古霉素	0	0	100
替加环素	0	0	100
利福平	0	3	97

抗菌药物	MRSCN阳性（n = 11）		MRSCN阴性（n = 23）		P值
抗菌药物	中介率（%）	耐药率（%）	中介率（%）	耐药率（%）	P值
青霉素	0	100	0	87	0.535
庆大霉素	0	18	0	0	0.098
左氧氟沙星	18	18	0	0	0.098
克林霉素	9	36	0	26	0.692
利奈唑胺	0	0	0	0	—
四环素	0	27	0	4	0.089
呋喃妥因	0	0	0	0	—
复方新诺明	0	18	0	9	0.580
苯唑西林	0	100	0	0	0.001
环丙沙星	18	18	4	0	0.098
莫西沙星	18	0	0	0	—
红霉素	0	45	4	17	0.111
喹努普汀/达福	0	0	0	0	—
万古霉素	0	0	0	0	—
替加环素	0	0	0	0	—
利福平	9	0	0	0	—

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