To investigate the infection of human papillomavirus (HPV) in local female patients and to provide valuable data for preventing HPV infection and cervical cancer occurrence.

Total of 21 types of HPV genotype were examined by PCR-Membrane hybridization technique in 778 women belonging to the outpatients of Shiyan Renmin Hospital.

Among those 778 tested women there are 289 HPV positive patients and the infection rate was 37.15%. As for the proportion of HPV infection, 74.74% were high-risk HPV infections and 17.65% were low-risk HPV infections, while the other 7.61% were the combination of high-risk and low-risk HPV infections. The top five genotypes of high-risk HPV infection are HPV16 (9.126%), HPV58 (7.455%), HPV52 (5.527%), HPV33 (3.599%) and HPV31 (2.314%). And the main genotypes of low-risk HPV infection were HPV6 (3.985%) and HPV11 (2.314%). In this region, the infection rate of high-risk HPV (30.59%) was significantly higher than that of low-risk HPV (9.38%) (χ² = 707.152, P < 0.001). And the infection rate of high-risk HPV multiple infection (21.34%) was also significantly higher compered with the infection rate of low-risk HPV multiple infection (2.00%) (χ² = 457.201, P < 0.001). While the infection rates for the monotonous genotype of HPV infection and the multiple genotypes of HPV infection were 78.89% and 21.11%, respectively. And there is no significant difference between the infection rates of HPV in five age groups (χ² = 4.096, P = 0.393). Totally high-risk HPV infection takes the majority of HVP infection in all groups.

HPV16, HPV52 and HPV58 were the most common genotypes of high-risk HPV infection, and HPV6 was the principal genotype of low-risk HPV infection. The main types of HPV infection was high-risk HPV infection and monotonous genotype of HPV infection. Multiple genotypes of HPV infections was mainly caused by high-risk HPV infection and high-risk and low-risk mixed HPV infections. HPV infection in women in this region is independent of age.