To analyze the intracranial infection rate, related risk factors and related prevention analysis after transsphenoidal surgery in patients with pituitary adenoma.

Total of 396 cases with pituitary adenoma patients from January 2009 to January 2015 were collected. The sex, age, history of diabetes, hypertension, operative time, intraoperative cerebrospinal fluid leakage, whether the existence of the diaphragmatic damage, bleeding, or cerebrospinal fluid leakage, postoperative drainage, no prophylactic use of antibiotics, postoperative application of hormone were analyzed, respectively.

Among the 396 cases with pituitary adenoma, 19 cases with postoperative intracranial infection, the infection rate was 4.7%. Postoperative cerebrospinal fluid leakage, indwelling drainage tube and glucocorticoid were risk factors of intracranial infection, while prophylactic antibiotics was the protective factor of reducing intracranial infection (all P < 0.05). The risk of intracranial infection after multiple factors Logistic regression analysis showed that the postoperative cerebrospinal fluid leakage, indwelling drainage tube, hormone therapy and prophylactic antibiotics application and intracranial infection were significantly correlated; postoperative cerebrospinal fluid leakage, indwelling drainage tube and hormone therapy were independent risk factors of postoperative intracranial infection.

Reduce postoperative cerebrospinal fluid leakage in operation, timely repair, strengthening the nursing of drainage tube indwelling operation, strict control of postoperative application of glucocorticoid indications, reasonable use of antibiotics could prevent the occurrence of intracranial infection.