To investigate the co-infection situation of patients with human immunodeficiency virus (HIV) infection or with acquired immune deficiency syndrome (AIDS) complicated with hepatitis B virus (HBV) or/and hepatitis C virus (HCV) infection.

The clinical data of 152 hospitalized patients with HIV/AIDS from August 2009 to March 2014 from Infection Center of Beijing Youan Hospita, Capital Medical University were analyzed, retrospectively, meanwhile, the clinical data of 20 healthy subjects were selected. The absolute logarithm of CD4⁺ T lymphocyte, blood routine, blood biochemical liver function, and coagulation index were analyzed, respectively.

Among the 152 hospitalized patients with HIV/AIDS, 80 cases with HIV infection, 44 cases with HIV/HBV co-infection, 23 cases with HIV/HCV co-infection, and 5 cases with HIV/HBV/HCV co-infection. There were 139 (91.4%) cases with CD4⁺ T lower than the reference interval in all the infection groups, compared with the control group, with significant differeces (F = 29.343, P < 0.001). The incidence rates of anemia in all the infection group was 59%-65%. Compared with the control group, the levels of hemoglobin (HGB), red blood cell (RBC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB) and creatinine (Cr) of patients in the infection groups were significantly different (all P < 0.05). The levels of prothrombin time (PT) and thrombin officially standardized ratio (INR) of patients in HIV/HBV co-infection group were significantly higher than those in HIV infection group and healthy control group (all P < 0.05).

HIV/AIDS patients complicated with HBV and HCV double or multiple infection was severe, this infection could easily lead to the occurrence of anemia, liver injury and coagulation function decreased.