Characteristics and influencing factors of serum sex hormones in female patients with chronic hepatitis B

doi:10.3877/cma.j.issn.1674-1358.2017.04.005

Abstract

Abstract:

Objective

To investigate characteristics and influencing factors of serum sex hormones in female patients with chronic hepatitis B.

Methods

Chronic hepatitis B patients (hepatitis group) and healthy women (control group) with 30 cases were collected in our hospital. Follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P), testosterone (T) and prolactin (PRL) in serum were measured by chemiluminescent immunoassay, and the levels of sex hormones and proportion of menopause were compared between the two groups.

Results

Compared with the group C, the levels of FSH and T in patients of CHB group were significantly increased, with significant differences (t =-2.119, P = 0.038; t =-2.312, P = 0.024), and E2 in patients of CHB group decreased significantly, with significant difference (t = 2.54, P = 0.014). The levels of LH, P and PRL in patients of the two group were without significant differences (all P > 0.05). The proportion of menopause of patients in CHB group was significantly higher than that of the control group (χ² = 4.3886, P = 0.0362).

Conclusion

Chronic hepatitis B ao lead the increase of levels of FSH and T in the serum of female patients, and the decrease of E2, and early menopause.

Key words: Female, Chronic hepatitis B, Sex hormone

Hongfang Li, Li Li, Wei Yi, Yuqing Bai, Qianying Zhuang, Minglong GAO. Characteristics and influencing factors of serum sex hormones in female patients with chronic hepatitis B[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(04): 335-338.

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组别	例数	年龄（岁）	体重（kg）	ALT（U/L）	AST（U/L）
对照组	30	50.2 ± 6.3	55.3 ± 5.3	30.4 ± 8.7	28.7 ± 7.9
肝炎组	30	51.9 ± 5.5	53.9 ± 6.2	76.1 ± 9.3	80.1 ± 10.4
t值		-1.113	0.940	-19.655	-21.556
P值		0.270	0.351	< 0.001	< 0.001

组别	例数	年龄（岁）	体重（kg）	ALT（U/L）	AST（U/L）
对照组	30	50.2 ± 6.3	55.3 ± 5.3	30.4 ± 8.7	28.7 ± 7.9
肝炎组	30	51.9 ± 5.5	53.9 ± 6.2	76.1 ± 9.3	80.1 ± 10.4
t值		-1.113	0.940	-19.655	-21.556
P值		0.270	0.351	< 0.001	< 0.001

组别	例数	FSH（mIU/ml）	E2（pg/ml）	LH（mIU/ml）	PRL（ng/ml）	P（ng/ml）	T（ng/ml）
对照组	30	28.23 ± 17.95	112.13 ± 64.93	19.09 ± 16.21	13.97 ± 5.34	0.55 ± 0.27	0.26 ± 0.09
肝炎组	30	41.22 ± 28.38	74.00 ± 50.34	24.21 ± 16.51	16.51 ± 4.51	0.65 ± 0.30	0.32 ± 0.11
t值		-2.119	2.542	-1.212	-1.990	-1.357	-2.312
P值		0.038	0.014	0.230	0.051	0.180	0.024

组别	例数	FSH（mIU/ml）	E2（pg/ml）	LH（mIU/ml）	PRL（ng/ml）	P（ng/ml）	T（ng/ml）
对照组	30	28.23 ± 17.95	112.13 ± 64.93	19.09 ± 16.21	13.97 ± 5.34	0.55 ± 0.27	0.26 ± 0.09
肝炎组	30	41.22 ± 28.38	74.00 ± 50.34	24.21 ± 16.51	16.51 ± 4.51	0.65 ± 0.30	0.32 ± 0.11
t值		-2.119	2.542	-1.212	-1.990	-1.357	-2.312
P值		0.038	0.014	0.230	0.051	0.180	0.024

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