To improve the understanding of the clinical features of severe fever with thrombocytopenia syndrome (SFTS) incorporative spontaneous intraventricular hemorrhage and invasive pulmonary aspergillosis (IPA).

The clinical manifestations, laboratory tests, radiographic, diagnosis and treatment of the case suferring from SFTS complicated with spontaneous intraventricular hemorrhage and IPA were analyzed through the literature review.

The prominent feature of SFTS was leukocytopenia and thrombocytopenia. Fever, malaise, cough and expectoration were the main clinical manifestations of SFTS. Damage of multiple-organ (such as liver, kidney, heart and coagulation) may occure. Spontaneous intraventricular hemorrhage was caused by dysfunction of blood coagulation. As it was hard to get the pathological data of lung, IPA should be diagnosed through risk factors, clinical symptoms of pulmonary infection, biological indicator so as to start empirical antifungal treatment as early as possible and reduce the mortality.

The occurrence of SFTS complicated with spontaneous intraventricular hemorrhage and IPA is rare in clinic. It may be related to leukocytopenia, thrombocytopenia, hypoimmunity and coagulopathy.