Abstract:

Hepatitis E virus (HEV) infection could cause acute or chronic hepatitis and liver failure and is associated with a number of extrahepatic manifestations. Neurological injuries were one kind of the most common extrahepatic manifestations of HEV infection. In recent years, case reports on hepatitis E neurological complications increased gradually. Guillain-Barre syndrome and neuralgic amyotrophy were the main neurological manifestations associated with acute HEV infection. Pathogenesis of HEV related neurological manifestations were controversial. Current research focuses on immune mediated injury and HEV directly neurotropic injury. Hepatitis E virus associated neurological manifestations and possible pathogenesis were reviewed in this paper.

Key words: Guillain-Barre syndrome, Hepatitis E virus, Neuralgic amyotrophy