Clinical analysis on 16 cases with epidemic cerebrospinal meningitis in Hotan, the Xinjiang Uygur Autonomous Region

doi:10.3877/cma.j.issn.1674-1358.2016.05.007

Abstract

Abstract:

Objective

To investigate the clinical characteristics of epidemic cerebrospinal meningitis in Hotan, the Xinjiang Uygur Autonomous Region.

Methods

The data of 16 patients with epidemic cerebrospinal meningitis who were admitted to Hotan People’s Hospital from March 2014 to March 2015 were analyzed, retrospectively. Epidemic season, age, clinical characteristics, laboratory examination, treatment and prognosis of patients were analyzed, respectively.

Results

Cerebrospinal meningitis mainly occurred on April to June. There were 11 children (68.75%) and 5 adults (31.25%) in this research. And 14 cases were with common type and 2 cases with fulminating type. Compared with the adult patients, the clinical manifestations of children were severe, and procalcitonin of children patients was higher (t =-2.668, P = 0.028).

Conclusions

There is a high occurrence of epidemic cerebrospinal meningitis in south of Xinjiang. The peak incidence of epidemic cerebrospinal meningitis occurs from April to June. Children were susceptible to epidemic cerebrospinal meningitis. The infection of children were more severe than adults. The immunization strategies are to enhance the rates of vaccine inoculation for epidemic cerebrospinal meningitis.

Key words: Epidemic cerebrospinal meningitis, Neisseria meningitides, Clinical characteristics

Xuesong Gao, Ruihong Zhang, Xueqin Zheng, Tianjiao Li, Xuefei Duan, Shun’ai Liu, Jun Cheng. Clinical analysis on 16 cases with epidemic cerebrospinal meningitis in Hotan, the Xinjiang Uygur Autonomous Region[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(05): 546-549.

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References 20

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临床表现		儿童（例）	成人(例）	总计[例（%）]
发热		11	5	16（100.00）
	≤ 39 ℃	6	3	9（56.25）
	> 39 ℃	5	2	7（43.75）
头痛		6	3	9（56.25）
恶心、呕吐		5	3	8（50.00）
抽搐		3	1	3（18.75）
意识障碍		5	2	7（43.75）
皮肤瘀点瘀斑		8	2	10（62.50）
颈抵抗		5	3	8（50.00）
克氏征/巴氏征		5	1	6（37.50）
血压下降/休克		3	0	3（18.75）
Ⅰ型呼吸衰竭		3	1	4（25.00）
分型
	普通型	0	14	14（87.50）
	暴发型	2	0	2（12.50）

临床表现		儿童（例）	成人(例）	总计[例（%）]
发热		11	5	16（100.00）
	≤ 39 ℃	6	3	9（56.25）
	> 39 ℃	5	2	7（43.75）
头痛		6	3	9（56.25）
恶心、呕吐		5	3	8（50.00）
抽搐		3	1	3（18.75）
意识障碍		5	2	7（43.75）
皮肤瘀点瘀斑		8	2	10（62.50）
颈抵抗		5	3	8（50.00）
克氏征/巴氏征		5	1	6（37.50）
血压下降/休克		3	0	3（18.75）
Ⅰ型呼吸衰竭		3	1	4（25.00）
分型
	普通型	0	14	14（87.50）
	暴发型	2	0	2（12.50）

组别	例数	血白细胞（× 10⁹/L）	C-反应蛋白（mg/L）	降钙素原（ng/L）	脑脊液白细胞（× 10⁹/L）
儿童	11	25.5±12.3	172.7±81.7	72.8±69.6	31.9±19.6
成人	5	20.9±8.1	153.1±42.9	10.5±5.2	4.4±4.1
统计量		t =-0.748	t =-0.447	t =-2.668	Z =-0.200
P值		0.469	0.663	0.028	0.841

组别	例数	血白细胞（× 10⁹/L）	C-反应蛋白（mg/L）	降钙素原（ng/L）	脑脊液白细胞（× 10⁹/L）
儿童	11	25.5±12.3	172.7±81.7	72.8±69.6	31.9±19.6
成人	5	20.9±8.1	153.1±42.9	10.5±5.2	4.4±4.1
统计量		t =-0.748	t =-0.447	t =-2.668	Z =-0.200
P值		0.469	0.663	0.028	0.841

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