To investigate the impact of clinical interventions for the pregnant patients with syphilis on pregnancy, and to provide guidance for clinical treatment of syphilis infection in the pregnant women.

Total of 90 cases of pregnant women infected with syphilis in our hospital from January 2010 to January 2015 were enroelled, according to clinical intervention time, the first screening of RPR titers and treatment of syphilis during pregnancy, they were divided into groups, while the pregnancy outcomes were analyzed.

The incidence of adverse pregnancy outcomes (including miscarriage, prematurity, stillbirth and congenial syphilis) before 20 weeks and after 20 weeks of pregnancy were 3.08% and 20.00%, with significant differences (χ² = 7. 521, P = 0.012). The incidence of adverse pregnancy outcomes were 1.67% (1/60), 20% (4/20) and 60% (6/10) in the standard treatment group (60 cases), nonstandard treatment group (20 cases) and non-treated group (10 cases), with significant differences (χ² = 13.863, P = 0.001). Among the 80 cases, there were 66 cases with titer ≤ 1︰4, 14 cases with titer≥ 1︰8. The incidence of adverse pregnancy outcomes was 1.52% (1/66) in ≤ 1︰4 group, and significantly lower than that of ≥ 1︰8 group which was 28.57% (4/14), with significant differences (χ² = 8.102, P = 0.011).

Early diagnosis and standard treatment of syphilis in pregnant women could improve the pregnancy outcome and the quality of birth population.