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中华实验和临床感染病杂志(电子版) ›› 2021, Vol. 15 ›› Issue (01) : 1 -6. doi: 10.3877/cma.j.issn.1674-1358.2021.01.001

所属专题: 文献

综述

糖基化修饰在包膜病毒感染过程中的作用
何玲玲1, 张成2, 周蓉蓉3, 魏红山1,()   
  1. 1. 100015 北京,首都医科大学附属北京地坛医院消化科
    2. 100730 北京,首都医科大学附属北京同仁医院消化科
    3. 266011 青岛市,青岛市立医院消化科
  • 收稿日期:2020-04-10 出版日期:2021-02-15
  • 通信作者: 魏红山
  • 基金资助:
    北京市自然科学基金(No. 7152073、7202071); 国家自然科学基金(No. 30872243、81071411)

Role of glycosylation in enveloped virus infection

Lingling He1, Cheng Zhang2, Rongrong Zhou3, Hongshan Wei1,()   

  1. 1. Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
    2. Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    3. Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266011, China
  • Received:2020-04-10 Published:2021-02-15
  • Corresponding author: Hongshan Wei
引用本文:

何玲玲, 张成, 周蓉蓉, 魏红山. 糖基化修饰在包膜病毒感染过程中的作用[J/OL]. 中华实验和临床感染病杂志(电子版), 2021, 15(01): 1-6.

Lingling He, Cheng Zhang, Rongrong Zhou, Hongshan Wei. Role of glycosylation in enveloped virus infection[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2021, 15(01): 1-6.

包膜病毒感染过程中,劫持宿主细胞的糖基化修饰系统对自身抗原进行修饰,籍此逃脱宿主的免疫监视,是病毒感染的重要机制。而且,包膜蛋白的糖基化修饰,一方面发挥抗原屏蔽效应,导致疫苗研发更为困难;另一方面,修饰的聚糖对抗原表位结构也具有空间重构效应。因此,包膜病毒的中和抗体与修饰聚糖的结构有关。除此之外,抗原蛋白的糖基化修饰也与病毒识别、黏附,组织嗜性,病毒颗粒组装的质量控制以及毒性与侵袭力有关。本文对该领域的研究现状做一综述。

During the infection process, the enveloped virus hijacked the glycosylation system of the host cell to modify its own antigen, and escape from the immune monitoring of the host. Moreover, the glycosylation modification to the envelope protein, which played the antigen shielding effect, made the development of vaccine more difficult. On the other hand, the structure of the modified polysaccharide against the major epitope also had a spatial reconstruction effect. Therefore, the construction of neutralizing antibodies to the enveloped virus was related to the structure of the modified glycan. In addition, the glycosylation modification of antigen proteins was also associated with virus recognition, adhesion, tissue tropism, quality control of viral particle assembly, toxicity and infectivity. The current advances in this field were reviewed in this article.

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