观察万古霉素复合型抗菌药物骨水泥植入治疗骨科术后感染的疗效。

选择深圳市罗湖区人民医院骨科2016年1月至2017年12月收治的22例骨科术后感染者为研究对象，给予万古霉素复合型抗菌药物骨水泥植入术治疗，并对疗效进行评价。

入组患者中20例炎性组织、肉芽培养出致病菌，2例患者未培养出致病菌。其中耐甲氧西林金黄色葡萄球菌占40%（8/20），表皮葡萄球菌占30%（6/20），肺炎克雷伯菌、铜绿假单胞菌和山羊葡萄球菌分别占15%（3/20）、10%（2/20）和5%（1/20）。22例患者首次手术与万古霉素复合型抗菌药物骨水泥链珠植入术间隔时长16～750 d，链珠在体内存留时长44～422 d。万古霉素复合型抗菌药物骨水泥植入术后均定期门诊随访4～15个月，其中感染控制者21例（95.45%），治愈者21例（95.45%），感染控制率和治愈率均为95.45%（21/22）。

万古霉素复合型抗菌药物骨水泥植入术治疗骨科感染疗效确切，可作为骨科术后感染治疗的首选方法。

To investigate the efficacy of vancomycin compound antibiotic bone cement implantation on treatment of postoperative orthopedic infection.

Total of 22 patients with postoperative infection in Orthopedics Department of Luohu District People’s Hospital in Shenzhen City from January 2016 to December 2017 were seleced. All of them were treated with the vancomycin compound antibiotic bone cement implantation, and the efficacy was evaluated.

The pathogenic bacteria were cultured from the inflammatory tissue and granulation of 20 patients, among which 40% (8/20) were methicillin-resistant Staphylococcus aureus (MRSA), 30% (6/20) were Staphylococcus epidermidis, 15% (3/20) were Klebsiella pneumoniae, 10% (2/20) were Pseudomonas aeruginosa and 5% (1/20) was Staphylococcus capillaries. The interval between the first operation of 22 patients and the implantation of vancomycin compound antimicrobial bone cement beads was 16-750 d, while the retention time of the beads in vivo was 44-422 d. All patients were followed up for 4-15 months after vancomycin compound antibiotic bone cement implantation, among whom, 21 cases (95.45%) were with infection controlled, 21 cases (95.45%) were cured, 1 case (4.55%) was not with infection controlled, and the infection control rate and cure rate were both 95.45% (21/22).

Vancomycin compound antibiotic bone cement implantation is effective in treatment of orthopaedic infection, it could be used as the first choice for the treatment of orthopedic postoperative infection.