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中华实验和临床感染病杂志(电子版) ›› 2019, Vol. 13 ›› Issue (03) : 177 -180. doi: 10.3877/cma.j.issn.1674-1358.2019.03.001

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综述

人类免疫缺陷病毒-1相关神经认知障碍危险因素研究进展
唐海杰1, 刘思思1, 金富军1, 付咏梅1, 董军1,()   
  1. 1. 510632 广州市,暨南大学基础医学院病理生理系,省中医药管理局重点实验室,粤港澳中枢神经再生研究院
  • 收稿日期:2018-10-30 出版日期:2019-06-15
  • 通信作者: 董军
  • 基金资助:
    国家自然科学基金项目(No. 8117134,No. 81471235); 广东省自然科学基金项目(No. 2014A030313360); 高等学校学科创新引智计划(No. B14036); 暨南大学科研培育与创新基金(No. 21617460); 广东省科学计划项目(No. 2010B010700016)

Progress on the risk factors of human immunodeficiency virus-1 associated neurocognitive disorder

Haijie Tang1, Sisi Liu1, Fujun Jin1, Yongmei Fu1, Jun Dong1,()   

  1. 1. Department of Pathophysiology in Jinan University; Key Laboratory of the State Administration of Traditional Chinese Medicine; GHM Institute of CNS Regeneration, Medical College of Jinan University, Guangzhou 510632, China
  • Received:2018-10-30 Published:2019-06-15
  • Corresponding author: Jun Dong
  • About author:
    Corresponding Author: Dong Jun, Email:
引用本文:

唐海杰, 刘思思, 金富军, 付咏梅, 董军. 人类免疫缺陷病毒-1相关神经认知障碍危险因素研究进展[J]. 中华实验和临床感染病杂志(电子版), 2019, 13(03): 177-180.

Haijie Tang, Sisi Liu, Fujun Jin, Yongmei Fu, Jun Dong. Progress on the risk factors of human immunodeficiency virus-1 associated neurocognitive disorder[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2019, 13(03): 177-180.

人类免疫缺陷病毒(HIV)感染人体外周血的同时入侵中枢神经系统(CNS),可以引发HIV-1相关神经认知障碍(HAND),主要表现为注意力不集中、感情淡漠和记忆障碍,导致患者日常工作生活不便。根据神经认知功能受损程度,HAND分为无症状性神经认知损害(ANI)、轻度神经认知紊乱(MND)和HIV相关痴呆症(HAD)3种类型。HAND目前已经成为AIDS患者重要的中枢神经系统并发症,AIDS患者进行联合抗逆转录病毒治疗(cART),病毒复制受到抑制,并发严重HIV相关痴呆者显著减少,生存期延长。目前HAND发病机制尚未明确,相关危险因素也需要进一步探索。本文对HAND相关危险因素的研究进展进行综述,为HAND诊断和发病机制研究提供新思路。

Human immunodeficiency virus (HIV) infects human peripheral blood, which also invade the central nervous system (CNS) and trigger HIV-1 associated neurocognitive disorder (HAND), mainly manifested in inattention, feelings indifferent and memory disorders, which could lead to inconvenience for daily work and life of patients. According to the degree of neurocognitive impairment, HAND is divided into three types: asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND) and HIV-associated dementia (HAD). HAND has become an essential chronic central nervous system complication of patients with acquired immunodeficiency syndrome (AIDS). Patients with AIDS have undergone combined antiretroviral therapy (cART). After the inhibition of systemic viral replication, the number of patients complicated with severe HIV-related dementia decreased significantly, and with prolongation of survival period. At present, the pathogenesis of HAND is not clear, and the related risk factors need to be furtherly explored. In this paper, the research progress of risk factors related to HAND is reviewed, which provides a new idea for the diagnosis and pathogenesis of HAND.

[1]
Singer EJ, Valdes-Sueiras M, Commins D, et al. Neurologic presentations of AIDS[J]. Neurol Clin,2010,28(1):253-275.
[2]
Schouten J, Cinque P, Gisslen M, et al. HIV-1 infection and cognitive impairment in the cART era: a review[J]. AIDS,2011,25(5):561-575.
[3]
Sacktor N, Nakasujja N, Skolasky RL, et al. HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda[J]. Clin Infect Dis,2009,49(5):780-786.
[4]
Boivin MJ, Ruel TD, Boal HE, et al. HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children[J]. AIDS,2010,24(8):1163-1170.
[5]
Cole JH, Underwood J, Caan MW, et al. Increased brain-predicted aging in treated HIV disease[J]. Neurology,2017,88(14):1349-1357.
[6]
Wade BS, Valcour VG, Wendelken-Riegelhaupt L, et al. Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort[J]. Neuroimage Clin,2015,9:564-573.
[7]
Jayadev S, Garden GA. Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders[J]. J Neuroimmune Pharmacol,2009,4(2):175-189.
[8]
Spector SA, Singh KK, Gupta S, et al. APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors[J]. AIDS,2010,24(10):1471-1479.
[9]
Morgan EE, Woods SP, Letendre SL, et al. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders[J]. J Neurovirol,2013,19(2):150-156.
[10]
Barnes LL, Arvanitakis Z, Yu L, et al. Apolipoprotein E and change in episodic memory in blacks and whites[J]. Neuroepidemiology,2013,40(3):211-219.
[11]
Tuminello ER, Han SD. The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations[J]. Int J Alzheimers Dis,2011,2011:726197.
[12]
Ho EL, Spudich SS, Lee E, et al. Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study[J]. AIDS Res Ther,2011,8:17.
[13]
Chai Q, Jovasevic V, Malikov V, et al. HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration[J]. Nat Commun,2017,8(1):1522.
[14]
Sevigny JJ, Albert SM, McDermott MP, et al. Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia[J]. Neurology,2004,63(11):2084-2090.
[15]
Valcour V, Shikuma C, Shiramizu B, et al. Higher frequency of dementia in older HIV-1 individuals: the Hawaii aging with HIV-1 cohort[J]. Neurology,2004,63(5):822-827.
[16]
Cole MA, Margolick JB, Cox C, et al. Longitudinally preserved psychomotor performance in long-term asymptomatic HIV-infected individuals[J]. Neurology,2007,69(24):2213-2220.
[17]
Millikin CP, Rourke SB, Halman MH, et al. Fatigue in HIV/AIDS is associated with depression and subjective neurocognitive complaints but not neuropsychological functioning[J]. J Clin Exp Neuropsychol,2003,25(2):201-215.
[18]
Brew BJ, Pemberton L, Blennow K, et al. CSF amyloid beta42 and tau levels correlate with AIDS dementia complex[J]. Neurology,2005,65(9):1490-1492.
[19]
Gisslén M, Krut J, Andreasson U, et al. Amyloid and tau cerebrospinal fluid biomarkers in HIV infection[J]. BMC Neurol,2009,9:63.
[20]
Valcour V, Paul R, Neuhaus J, et al. The Effects of Age and HIV on Neuropsychological Performance[J]. J Int Neuropsychol Soc,2011,17(1):190-195.
[21]
Ciccarelli N, Fabbiani M, Baldonero E, et al. Effect of aging and human immunodeficiency virus infection on cognitive abilities[J]. J Am Geriatr Soc,2012,60(11):2048-2055.
[22]
Cysique LA, Waters EK, Brew BJ. Central nervous system antiretroviral efficacy in HIV infection: a qualitative and quantitative review and implications for future research[J]. BMC Neurol,2011,11:148.
[23]
Su T, Mutsaerts HJ, Caan MW, et al. Cerebral blood flow and cognitive function in HIV-infected men with sustained suppressed viremia on combination antiretroviral therapy[J]. AIDS,2017,31(6):847-856.
[24]
Fabbiani M, Ciccarelli N, Tana M, et al. Cardiovascular risk factors and carotid intima-media thickness are associated with lower cognitive performance in HIV-infected patients[J]. HIV Med,2013,14(3):136-144.
[25]
McCutchan JA, Marquie-Beck JA, Fitzsimons CA, et al. Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder[J]. Neurology,2012,78(7):485-492.
[26]
Satz P, Morgenstern H, Miller EN, et al. Low education as a possible risk factor for cognitive abnormalities in HIV-1: findings from the multicenter AIDS Cohort Study (MACS)[J]. J Acquir Immune Defic Syndr,1993,6(5):503-511.
[27]
Becker JT, Kingsley LA, Molsberry S, et al. Cohort Profile: Recruitment cohorts in the neuropsychological substudy of the Multicenter AIDS Cohort Study[J]. Int J Epidemiol,2015,44(5):1506- 1516.
[28]
Rabkin JG, Ferrando SJ, van Gorp W, et al. Relationships among apathy, depression, and cognitive impairment in HIV/AIDS[J]. J Neuropsychiatry Clin Neurosci,2000,12(4):451-457.
[29]
Valcour V, Sithinamsuwan P, Letendre S, et al. Pathogenesis of HIV in the central nervous system[J]. Curr HIV/AIDS Rep,2011,8(1):54-61.
[30]
Robertson KR, Su Z, Margolis DM, et al. Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort[J]. Neurology,2010,74(16):1260-1266.
[31]
Crystal HA, Weedon J, Holman S, et al. Associations of cardiovascular variables and HAART with cognition in middle-aged HIV-infected and uninfected women[J]. J Neurovirol,2011,17(5):469-476.
[32]
Xu Z, Asahchop EL, Branton WG, et al. MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology[J]. PLoS Pathog,2017,13(6):e1006360.
[33]
Kiko T, Nakagawa K, Tsuduki T, et al. MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer’s disease[J]. J Alzheimers Dis,2014,39(2):253-259.
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