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中华实验和临床感染病杂志(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 89 -92. doi: 10.3877/cma.j.issn.1674-1358.2019.02.001

所属专题： 文献；

综述

高毒力肺炎克雷伯菌研究进展
陈辞言1, 杜艳1,†()   
  1. 1. 650032　昆明市，昆明医科大学第一附属医院检验科、云南省实验诊断研究所、中国云南省检验医学重点实验室
  • 收稿日期:2018-09-14 出版日期:2019-04-15
  • 通信作者: 杜艳
  • 基金资助:
    2017年云南省医学学科带头人培养项目(No. D-2017023)

Progress on hypervirulent Klebsiella pneumoniae

Ciyan Chen1, Yan Du1,†()   

  1. 1. Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Institute of Laboratory Diagnosis; Yunnan Key Laboratory of Laboratory Medicine, Kunming 650032, China
  • Received:2018-09-14 Published:2019-04-15
  • Corresponding author: Yan Du
  • About author:
    Corresponding author: Du Yan, Email:
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陈辞言, 杜艳. 高毒力肺炎克雷伯菌研究进展[J]. 中华实验和临床感染病杂志(电子版), 2019, 13(02): 89-92.

Ciyan Chen, Yan Du. Progress on hypervirulent Klebsiella pneumoniae[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2019, 13(02): 89-92.

肺炎克雷伯菌（KP）为常见的医院获得性和社区获得性感染病原菌，近年来肺炎克雷伯菌所致的肝脓肿患者例数逐渐增加，且多伴随肝外感染，故得到了广泛关注。这种引起肝脓肿的肺炎克雷伯菌具有较高毒力以及高黏液特性，易导致健康个体感染，因此将其定义为高毒力肺炎克雷伯菌（hvKP）。高毒力肺炎克雷伯菌感染的临床特点、对抗菌药物的敏感性以及分子生物学特性，均不同于传统的肺炎克雷伯菌（cKP），故对高毒力肺炎克雷伯菌的毒力基因进行研究有助于明确该细菌的致病机制，有助于尽早诊断和治疗该细菌导致的感染，有效改善高毒力肺炎克雷伯菌感染者的预后。

关键词: 高毒力肺炎克雷伯菌, 毒力基因, 高黏液性, 铁载体, 耐药特点

Klebsiella pneumoniae (KP) is a common hospital-acquired and community-acquired pathogen. In recent years, patients with liver abscess caused by KP and accompanying extrahepatic infection have gradually increased, and causing widespread concern. The pathogen, which caused liver abscess, and characterized by high virulance and high mucinous, is easy to cause infection among healthy individual. Therefore, it is defined as hypervirulent Klebsiella pneumoniae (hvKP). Compared with classic Klebsiella pneumoniae (cKP), the clinical characteristics of hvKP infection, sensitivity to antibiotics, and molecular biological characteristics are significantly different. It will be a fine way to understand the pathogenic mechanism of the bacteria by studying the virulence gene of hvKP, which may help to early diagnose and medical treatment of the infection caused by the bacteria, and will effectively improve the prognosis of patients with hvKP infection.

Key words: Hypervirulent Klebsiella pneumoniae, Virulence gene, Hypermucoviscous, Siderophores, Drug-resistance characteristic
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