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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (03) : 216 -220. doi: 10.3877/cma.j.issn.1674-1358.2018.03.003

所属专题: 文献

综述

戊型肝炎研究进展
赵一鸣1, 刘秀红2,(), 李伟华2, 刘晓霓2, 李宁2   
  1. 1. 100730 北京,北京协和医院基本外科
    2. 100069 北京,首都医科大学附属北京佑安医院/北京市肝病研究所/北京市肝炎与肝癌精准医疗及转化工程技术研究中心
  • 收稿日期:2017-08-19 出版日期:2018-06-15
  • 通信作者: 刘秀红
  • 基金资助:
    北京市属医学科研所公益发展改革试点项目(No.京医研2016-2); 北京市肝病研究所所内课题(No. 2018-3-4); 首都临床特色应用研究与成果推广项目(No. Z151100004015081)

Recent advances on hepatitis E

Yiming Zhao1, Xiuhong Liu2,(), Weihua Li2, Xiaoni Liu2, Ning Li2   

  1. 1. Peking Union Medical College Hospital, Beijing 100730, China
    2. Beijing You’an Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, 100069 Beijing, China
  • Received:2017-08-19 Published:2018-06-15
  • Corresponding author: Xiuhong Liu
  • About author:
    Corresponding author: Liu Xiuhong, Email:
引用本文:

赵一鸣, 刘秀红, 李伟华, 刘晓霓, 李宁. 戊型肝炎研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2018, 12(03): 216-220.

Yiming Zhao, Xiuhong Liu, Weihua Li, Xiaoni Liu, Ning Li. Recent advances on hepatitis E[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(03): 216-220.

全球每年约2 000万人感染戊型肝炎病毒(HEV),虽然戊型肝炎病死率在一般人群中低于1%,但HEV感染妊娠患者的病死率可高达30%。此外,免疫功能低下人群(器官移植、放化疗和HIV感染等)HEV感染所导致的慢性戊型肝炎给临床治疗带来新的问题和挑战。过去仅有戊型肝炎病例输入的发达国家,近年来亦频繁出现本土散发病例,HEV感染已成为全球重要的公共卫生问题。本文关注近两年来的研究数据,回顾HEV生物学、流行病学特征、肝外表现、治疗及诊断的最新进展,阐明戊型肝炎的研究方向是在与人类生活密切接触的偶蹄类动物中寻找新orthohepevirus基因型;更好地了解准包膜HEV(eHEV)包膜起源和结构以及参与eHEV释放和重返细胞宿主因素/途径,有助于靶向治疗性干预。

There are about 20 million people infected with hepatitis E virus (HEV) in the world every year. Although the mortality rate of hepatitis E is less than 1% in the general population, the mortality rate of pregnant women with hepatitis E can be as high as 30%. In addition, chronic hepatitis E caused by HEV infection in immunocompromised population (organ transplantation, radiotherapy and chemotherapy, HIV, etc.) brings new problems and challenges to clinical treatment. In the past, only developed countries with imported cases, frequent sporadic cases of local infections in recent years, HEV infection has become an important global public health problem. This paper reviews the data of the last two years and reported the new progress of HEV biology epidemiology, the extrahepatic manifestations, diagnosis and treatment. This article suggests that the direction of hepatitis E research is to search for new orthohepevirus genotypes in the genes of the hoofed animals closely related to human life. For targeted therapies, it is necessary to understand the origin and structure of the quasi enveloped hepatitis E virus (quasi-enveloped HEV, eHEV) and to participate in eHEV release and return to host cytokine and pathway.

[1]
Khuroo MS, Khuroo MS, Khuroo NS. Hepatitis E: discovery, global impact, control and cure[J]. World J Gastroenterol,2016,22(31):7030- 7045.
[2]
WHO. Hepatitis E fact sheet[EB/OL]. 2017.

URL    
[3]
Ren X, Wu P, Wang LP, et al. Changing epidemiology of hepatitis A and hepatitis E viruses in China,1990-2014[J]. Emerg Infect Dis,2017,23(2):276-277.
[4]
Jin H, Zhao Y, Zhang X, et al. Case-fatality risk of pregnant women with acute viral hepatitis type E: A systematic review and meta-analysis[J]. Epidemiol Infect,2016,144(10):2098-2106.
[5]
ICTV. Virus Taxonomy: 2015 release[EB/OL]. 2017.

URL    
[6]
Sridhar S, Teng JLL, Chiu TH, et al. Hepatitis E virus genotypes and evolution: emergence of camel hepatitis E variants[J]. Int J Mol Sci,2017,18(4):869.
[7]
Rasche A, Saqib M, Liljander AM, et al. Hepatitis E virus infection in dromedaries, North and East Africa, United Arab Emirates, and Pakistan, 1983-2015[J]. Emerg Infect Dis,2016,22(7):1249-1252.
[8]
Debing Y, Moradpour D, Neyts J, et al. Update on hepatitis E virology: implications for clinical practice[J]. J Hepatol,2016,65(1):200-212.
[9]
Hartl J, Otto B, Madden RG, et al. Hepatitis E seroprevalence in Europe: a meta-analysis[J]. Viruses,2016,8(8):211.
[10]
Nair VP, Anang S, Subramani C, et al. Endoplasmic reticulum stress induced synthesis of a novel viral factor mediate sufficient replication of genotype-1 hepatitis E virus[J]. PLoS Pathog,2016,12(4):e1005521.
[11]
Huang F, Li Y, Yu W, et al. Excretion of infectious hepatitis E virus into milk in cows imposes high risks of zoonosis[J]. Hepatology,2016,64(2):350-359.
[12]
Khuroo MS, Khuroo MS, Khuroo NS. Transmission of hepatitis E virus in developing countries[J]. Viruses,2016,8(9):253.
[13]
Cui W, Sun Y, Xu A, et al. Hepatitis E seroprevalence and related risk factors among seafood processing workers: A cross-sectional survey in Shandong Province, China[J]. Int J Infect Dis,2016,49:62-66.
[14]
Yin X, Ambardekar C, Lu Y, et al. Distinct entry mechanisms for non-enveloped and quasi-envelop hepatitis E virus[J]. J Virol,2016,90(8):4232-4242.
[15]
Allweiss L, Gass S, Giersch K, et al. Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation[J]. J Hepatol,2016,64(5):1033-1040.
[16]
Van de Garde, Pas SD, van der Net, et al. Hepatitis E virus (HEV) genotype 3 infection of human liver chimericmiceas a model for chronic HEV infection[J]. J Virol,2016,90(9):4394-4401.
[17]
Yin X, Li XL, Feng ZD. Role of envelopment in the HEV life cycle[J]. Viruses,2016,8(8):E229.
[18]
Pischke S, Schwarze-Zander C, Bremer B, et al. Hepatitis E virus seroprevalence rate in HIV-infected patients in Germany: a comparison of two commercial assays[J]. Intervirology,2015,58(8):283-287.
[19]
O’Marion F, Abravanel S, Lhomme, et al. Hepatitis E in transplantation[J]. Cur Infect Dis Rep,2016,18(3):1-8.
[20]
Haffar S, Bazerbachi F, Garg S, et al. Frequency and prognosis of acute pancreatitis associated with acute hepatitis E: Asystematic review[J]. Pancreatology,2015,15(4):321-326.
[21]
Tejero H, Montero F, Nuno JC. Theories of lethal mutagenesis: from error catastrophe to lethal defection[J]. Curr Top Microbiol Immunol,2016,392:161-179.
[22]
Todt D, Gisa A, Radonic A, et al. In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome[J]. Gut,2016,65(10):1733-1743.
[23]
Dao Thi VL, Debing Y, Wu X, et al. Sofosbuvir inhibi the patitis E virus replicationin vitro and results in an additive effect when combined with ribavirin[J]. Gastroenterology,2016,150(1):82-85.
[24]
Nan Y, Ma Z, Kannan H, et al. Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers[J]. Antiviral Res,2015,120:134-139.
[25]
Smith DB, Simmonds P. Hepatitis E virus and fulminant hepatitis-a virus or host-specific pathology?[J]. Liver Int,2015,35(4):1334-1340.
[26]
Kamar N, Lhomme S, Abravanel F, et al. An early viral response predicts the virological response to ribavirin in hepatitis E virus organ transplant patients[J]. Transplantation,2015,99(10):2124-2131.
[27]
Abravanel F, Lhomme S, Rostaing L, et al. Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse[J]. Clin Infect Dis,2015,60(1):96-99.
[28]
Irshad M, Gupta P, Mankotia DS, et al. Multiplex qPCR for serodetection and serotyping ofhepatitis viruses: A brief review[J]. World J Gastroenterol,2016,22(20):4824-4834.
[29]
Wang L, Xia J, Wang L, et al. Experimental infection of rabbits with genotype 3 hepatitis E virus produced both chronicity and kidney injury[J]. Gut,2017,66(3):561-562.
[30]
Li TC, Yang T, Yoshizaki S, et al. Ferret hepatitis E virus infection induces acute hepatitis and persistent infection in ferrets[J]. Vet Microbiol,2016,183:30-36.
[31]
Yang Y, Shi R, She R, et al. Effect of swine hepatitis E virus on the livers of experimentally infected Mongolian gerbils by swine hepatitis E virus[J]. Virus Res,2015,208:171-179.
[32]
Devhare PB, Desai S, Lole KS. Innate immune responses in humanhepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies[J]. Sci Rep,2016,6:26827.
[33]
Yin X, Ambardekar C, Lu Y, et al. Distinct entry mechanisms for nonenveloped and quasi-enveloped hepatitis E viruses[J]. J Virol,2016,90(8):4232-4242.
[34]
Li SW, Zhao Q, Wu T, et al. The development of a recombinant hepatitis E vaccine HEV 239[J]. Hum Vaccin Immunother,2015,11(4):908-914.
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