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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (03) : 221 -224. doi: 10.3877/cma.j.issn.1674-1358.2018.03.004

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综述

获得性免疫缺陷综合征患者骨质疏松脆性骨折研究进展
王帅1, 赵汝岗1, 张强1,()   
  1. 1. 100015 北京,首都医科大学附属北京地坛医院骨科
  • 收稿日期:2017-11-12 出版日期:2018-06-15
  • 通信作者: 张强

Progress of fragility fracture in patients with acquired immune deficiency syndrome

Shuai Wang1, Rugang Zhao1, Qiang Zhang1,()   

  1. 1. Orthopedic Department, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • Received:2017-11-12 Published:2018-06-15
  • Corresponding author: Qiang Zhang
  • About author:
    Corresponding author: Zhang Qiang, Email:
引用本文:

王帅, 赵汝岗, 张强. 获得性免疫缺陷综合征患者骨质疏松脆性骨折研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2018, 12(03): 221-224.

Shuai Wang, Rugang Zhao, Qiang Zhang. Progress of fragility fracture in patients with acquired immune deficiency syndrome[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(03): 221-224.

获得性免疫缺陷综合征(AIDS)在普通人群中的发病率逐渐增加,随着高效抗逆转录病毒治疗(HAART)的应用,AIDS患者的病死率逐渐降低,但骨质疏松脆性骨折的发生率显著高于健康人群。本综述主要介绍AIDS患者骨质疏松脆性骨折的发生率和危险因素等,人类免疫缺陷病毒(HIV)和HAART对成骨细胞、破骨细胞OPG/RANK/RANKL系统的作用机制和不良反应;简述AIDS患者骨质疏松脆性骨折药物预防和治疗方法。

The incidence of acquired immune deficiency syndrome (AIDS) in general population increased gradually, but the mortality of patients with AIDS decreased gradually with the application of highly effective antiretroviral therapy, and the incidence of fragility fracture in patients with AIDS is significantly higher than that of normal population. This paper introduces the occurrence of fragility fracture of AIDS, the effect of human immunodeficiency virus (HIV) and highly active antiretroviral therapy (HAART) on osteoblasts and osteoclasts OPG/RANK/RANKL system. Prevention and treatment of drugs to AIDS patients with fragility fracture was also introduced.

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