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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (01) : 15 -19. doi: 10.3877/cma.j.issn.1674-1358.2018.01.004

所属专题: 指南与规范 文献 指南共识

综述

合理抗病毒治疗在实现慢性乙型肝炎指南治疗目标中的应用
张元山1,()   
  1. 1. 242000 宣城市,安徽省宣城市中心医院感染科
  • 收稿日期:2017-02-19 出版日期:2018-02-15
  • 通信作者: 张元山

Application of reasonable antiviral treatment of chronic hepatitis B in implementation of treatment goals in the guidelines

Yuanshan Zhang1,()   

  1. 1. Department of Infectious Diseases, The Central Hospital of Xuancheng, Xuancheng 242000, China
  • Received:2017-02-19 Published:2018-02-15
  • Corresponding author: Yuanshan Zhang
  • About author:
    Corresponding auther: Zhang Yuanshan, Email:
引用本文:

张元山. 合理抗病毒治疗在实现慢性乙型肝炎指南治疗目标中的应用[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(01): 15-19.

Yuanshan Zhang. Application of reasonable antiviral treatment of chronic hepatitis B in implementation of treatment goals in the guidelines[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(01): 15-19.

本文就核苷类药物(NAs)和干扰素(IFN)两类药物的作用机理和特点以及如何选择和应用来实现慢性乙型肝炎治疗目标进行探讨。为逐步达到满意甚至理想的治疗目标,通过评估和监测乙型肝炎病毒表面抗原(HBsAg)和乙型肝炎病毒e抗原(HBeAg)定量的变化,需要在适合的时机联合序贯干扰素治疗。合理的抗病毒治疗可最大限度地提高慢性乙型肝炎的疗效。

How to choose and use interferon (IFN) and nucleoside analogues (NAs) to achieve the chronic hepatitis B the treatment goals, and the mechanism and characteristics of the two kinds of drugs were investigated. In order to gradually achieve the satisfied even the ideal milestone, it needs combination and sequential application of interferon therapy at the right time through evaluating and monitoring the changes of HBsAg and HBeAg quantity. Reasonable antiviral therapy could improve the efficacy of chronic hepatitis B to the maximum extent.

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