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中华实验和临床感染病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (03) : 265 -268. doi: 10.3877/cma.j.issn.1674-1358.2016.03.003

综述

慢性乙型肝炎母婴传播的影响因素新进展
杨敏1, 刘映霞2,†()   
  1. 1. 518112　深圳市，南华大学深圳市第三人民医院感染科
    2. 518112　深圳市，传染病学国家重点学科，深圳市第三人民医院感染科
  • 收稿日期:2015-10-27 出版日期:2016-06-15
  • 通信作者: 刘映霞
  • 基金资助:
    深圳市科技计划项目(No. JCYJ20150402111430629); 深圳市新发传染病重点专科(No. 201161)

New progress of the influence factors of mother-to-child transmission of chronic hepatitis B

Min Yang1, Yingxia Liu2,†()   

  1. 1. Department of Infectious Diseases, University of South China Shenzhen Third People’s Hospital, Shenzhen 518112, China
    2. State Key Discipline of Infectious Diseases, Department of Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen 518112, China
  • Received:2015-10-27 Published:2016-06-15
  • Corresponding author: Yingxia Liu
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杨敏, 刘映霞. 慢性乙型肝炎母婴传播的影响因素新进展[J]. 中华实验和临床感染病杂志(电子版), 2016, 10(03): 265-268.

Min Yang, Yingxia Liu. New progress of the influence factors of mother-to-child transmission of chronic hepatitis B[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 265-268.

乙型肝炎病毒（HBV）传播的主要途径是母婴传播，对母亲HBsAg阳性的新生儿进行联合免疫（HBIG +乙肝疫苗），母婴阻断成功率可达90%～95%，但对于高病毒载量的母亲，在联合免疫的情况下，仍有8%～32%的婴儿在围生期感染HBV，在围产期感染HBV者有90%发展成慢性感染，这些慢性感染者有15%～25%死于肝硬化和肝癌。因此，对HBV感染的孕妇进行管理及制定阻断HBV母婴传播的策略对降低母婴传播率至关重要。由于人们对此类问题的敏感性，临床试验难以进行。本文将从HBV母婴传播模式和影响因素等方面进行综述。

关键词: 肝炎, 乙型, 母婴传播模式, 影响因素

HBV is mainly transmitted via mother-to-child transmission (MTCT), combined immunization (HBIG + hepatitis B vaccination) had reduced 90%-95% newborns MTCT, but for mothers of high viral load, there were still 8%-32% newborns infected with HBV. Over 90% of perinatally acquired infections progress to chronic HBV infection. There were 15%-25% of these chronic infected people will die of cirrhosis or liver cancer eventually. Therefore, the management of HBsAg-positive pregnant women and the strategy of blocking MTCT are crucial to reduce the MTCT rate. Due to the sensitivity of such problems, clinical trials are difficult. Here, the routes of transmission and influencing factors of MTCT were overviewed.

Key words: Chronic hepatitis B, Mother-to-child transmission mode, Influencing factors
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