探讨妊娠晚期合并水痘对妊娠结局的影响。

收集2011年1月至2014年11月首都医科大学附属北京地坛医院妊娠晚期合并水痘的住院孕妇15例，回顾性分析水痘-带状疱疹病毒对母婴的影响。

15例晚期妊娠合并水痘的患者中，孕29～34周患者5例（占33.3%），均无严重并发症，经积极治疗10～14 d痊愈出院，足月后3例孕妇自然分娩，2例孕妇剖宫产分娩，产妇无不良结局，新生儿阿氏评分、体重均在正常范围，随访新生儿30 d无水痘感染病例。孕37～40周患者10例（占66.7%），治疗过程中分娩8例，其中4例孕妇剖宫产分娩，4例孕妇自然临产分娩；孕妇感染7 d内分娩者3例，感染7 d以上分娩者5例，其中孕妇感染第5天自然分娩的1例新生儿感染水痘，经积极治疗痊愈出院，其余7例新生儿阿氏评分、体重均在正常范围，随访30 d均无水痘感染；8例产妇治疗7～10 d均痊愈出院；另外2例孕妇水痘痊愈后外院分娩，追访母儿分娩顺利，新生儿随访30 d无水痘感染。孕29～34周和孕37～40周感染水痘的两组孕妇，足月后分娩的新生儿水痘感染率分别为0%和10%，差异具有统计学意义（P = 0.048）。

妊娠晚期合并水痘的孕妇应积极给予抗病毒和对症治疗以减轻临床症状、避免出现严重并发症，同时尽量推迟分娩，以减少新生儿水痘的发生。

To investigate the outcome of the pregnancy women complicated with varicella in third trimester.

The clinical data of 15 pregnancy women complicated with varicella in third trimester from January 2011 to November 2014 in Beijing Ditan Hospital, Capital Medical University were analyzed, retrospectively.

Among the 15 cases, 5 (33.3%) cases were 29-34 weeks pregnant, they were with no serious complications and were cured after antiviral treatment in 2 weeks. Three patients of full-term pregnancy were natural birth, 2 patients were cesarean delivery, maternal were well recovered. Apgar scoring and weights of newborns were in the normal range, and they were not infected during 30 days followed up. Ten (66.7%) cases were 37-40 weeks pregnant. Eight patients delivered during treatment. Among those patients, 4 cases were cesarean delivery, and the rest were natural childbirth. And 3 patients delivered within 7 days of infection, and 5 patients had more than 7 days of infection. One newborn was infected because his mother was infected in the fifth day before delivered, but the baby’s symptoms were not serious and was cured by antiviral treatment. The Apgar scoring and weight of the remaining seven newborns were in the normal range, they were not infected during 30 days followed up. Eight delivery women were cured after 7-10 days antiviral treatment in hospital, another 2 pregnant women were cured and delivered after discharged from hospital. It had no adverse effect on the pregnancy and infants. The newborns were not infected during 30 days followed up. Varicella infection rates of newborn were 0% and 10% respectively for delivery women between 29-34 weeks pregnant and 37-40 weeks pregnant, with significant differences (P = 0.048).

It is very important for the pregnancy women complicated with varicella in third trimester to give positive antiviral therapy and symptomatic treatment. Trying best to delay the delivery is able to decrease the incidence of neonatal chickenpox potentially.