为了实现世界卫生组织提出的"2030年消除病毒性肝炎作为重大公共卫生威胁"的目标,中华医学会感染病学分会和肝病学分会于2019年组织国内有关专家,以国内外慢性乙型肝炎病毒感染的基础和临床研究进展为依据,结合现阶段我国的实际情况,更新形成了《慢性乙型肝炎防治指南(2019年版)》,为慢性乙型肝炎的预防、诊断和治疗提供重要依据。
How to choose and use interferon (IFN) and nucleoside analogues (NAs) to achieve the chronic hepatitis B the treatment goals, and the mechanism and characteristics of the two kinds of drugs were investigated. In order to gradually achieve the satisfied even the ideal milestone, it needs combination and sequential application of interferon therapy at the right time through evaluating and monitoring the changes of HBsAg and HBeAg quantity. Reasonable antiviral therapy could improve the efficacy of chronic hepatitis B to the maximum extent.