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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (06) : 521 -525. doi: 10.3877/cma.j.issn.1674-1358.2018.06.001

所属专题: 文献

论著

人类免疫缺陷病毒感染初治男性患者糖脂代谢横断面研究
王延雪1, 胡虹英1,(), 李新刚1, 徐文晶1, 倪量1   
  1. 1. 100015 北京,首都医科大学附属北京地坛医院内分泌科
  • 收稿日期:2018-04-08 出版日期:2018-12-15
  • 通信作者: 胡虹英

A cross-sectional study of glucose and lipid metabolism in highly active antiretroviral therapy-naïve male patients with human immunodeficiency virus infection

Yanxue Wang1, Hongying Hu1,(), Xingang Li1, Wenjing Xu1, Liang Ni1   

  1. 1. Endocrinology Department, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • Received:2018-04-08 Published:2018-12-15
  • Corresponding author: Hongying Hu
  • About author:
    Corresponding author: Hu Hongying, Email:
引用本文:

王延雪, 胡虹英, 李新刚, 徐文晶, 倪量. 人类免疫缺陷病毒感染初治男性患者糖脂代谢横断面研究[J/OL]. 中华实验和临床感染病杂志(电子版), 2018, 12(06): 521-525.

Yanxue Wang, Hongying Hu, Xingang Li, Wenjing Xu, Liang Ni. A cross-sectional study of glucose and lipid metabolism in highly active antiretroviral therapy-naïve male patients with human immunodeficiency virus infection[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(06): 521-525.

目的

研究未进行高效抗逆转录病毒治疗(HAART)的初治男性人类免疫缺陷病毒(HIV)感染者的糖脂代谢情况。

方法

比较140例尚未进行HAART治疗的初治男性HIV/AIDS患者(病例组)与140例健康者(对照组)的体重指数、空腹血糖、血脂和血尿酸等代谢参数的差异。

结果

与对照组相比,病例组患者空腹血糖显著升高(5.76 mmol/L vs. 5.16 mmol/L,t = 5.265、P = 0.008),BMI显著降低(21.79 kg/m2 vs. 23.07 kg/m2t =-4.921、P < 0.001),甘油三酯显著升高(1.45 mmol/L vs. 1.16 mmol/L,t = 3.516、P = 0.001),血尿酸显著升高(411.66 μmol/L vs. 350.17 μmol/L,t = 7.167、P < 0.001),高密度脂蛋白胆固醇显著降低(0.98 mmol/L vs. 1.29 mmol/L,t =-7.275,P < 0.001),差异均具有统计学意义。病例组患者总胆固醇及低密度脂蛋白胆固醇水平均随CD4+ T细胞计数下降而下降,高密度脂蛋白胆固醇水平与HIV RNA载量呈负相关。

结论

初治男性HIV/AIDS患者HAART治疗前已出现空腹血糖升高及血脂等代谢紊乱,与CD4+ T细胞计数及HIV RNA载量相关,治疗过程中需定期监测代谢指标,评估心血管疾病风险。

Objective

To investigate the metabolism of glucose and lipid in highly active antiretroviral therapy (HAART)-na?ve male cases with human immunodeficiency virus (HIV) infection.

Methods

The metabolic parameters of body mass index (BMI), fasting blood glucose (FPG), blood lipid and uric acid were compared between 140 HAART-na?ve HIV/AIDS male patients (research group) and 140 healthy subjects (control group), respectively.

Results

Compared with control group, FPG of patients in research group increased significantly (5.76 mmol/L vs. 5.16 mmol/L; t = 5.265, P = 0.008), BMI reduced significantly (21.79 kg/m2 vs. 23.07 kg/m2; t =-4.921, P < 0.001), triglyceride increased significantly (1.45 mmol/L vs. 1.16 mmol/L; t = 3.516, P = 0.001), serum uric acid increased significantly (411.66 μmol/L vs. 350.17 μmol/L; t = 7.167, P < 0.001), high density lipoprotein cholesterol decreased significantly (0.98 mmol/L vs. 1.29 mmol/L; t =-7.275, P < 0.001), all with significant differences. The levels of total cholesterol and low density lipoprotein cholesterol decreased with the decrease of CD4+ T cell count in the research group. The level of high density lipoprotein cholesterol was negatively correlated with HIV RNA load.

Conclusions

Before the treatment of HAART in male patients with HIV/AIDS, fasting blood glucose and blood lipids have been increased, which is related to the counts of CD4+ T cells and the load of HIV RNA. The metabolic indexes should be monitored regularly in the course of treatment to evaluate the risk of cardiovascular disease.

表1 病例组患者与对照组的糖脂等代谢参数(±s
表2 不同CD4+ T细胞计数组HIV/AIDS患者代谢参数(±s
表3 糖脂等代谢参数与HIV RNA载量的相关性(±s
图1 HIV RNA载量与HDL-C相关性曲线
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