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中华实验和临床感染病杂志(电子版)

中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 179 -182. doi: 10.3877/cma.j.issn.1674-1358.2018.02.016

所属专题： 文献；

临床论著

戊型肝炎患者血清GP73变化特征及意义
蒋煜1, 徐飞2, 胡居龙3, 华文浩2, 李坪3, 魏红山3,†()   
  1. 1. 100015　北京，首都医科大学附属北京地坛医院消化科
    2. 100015　北京，首都医科大学附属北京地坛医院
  • 收稿日期:2017-01-31 出版日期:2018-04-15
  • 通信作者: 魏红山
  • 基金资助:
    国家自然科学基金(No. 81271901); 北京市自然科学基金(No. 7152073); 首都特色临床研究(No. Z141107002514132); 首都医学发展科研基金(No. 2014-2-2171)

Characteristics of serum GP73 for patients with hepatitis E and its clinical significances

Yu Jiang1, Xu Fei2, Julong Hu3, Wenhao Hua2, Ping Li3, Hongshan Wei3,†()   

  1. 2. Clinical Lab, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
    3. Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • Received:2017-01-31 Published:2018-04-15
  • Corresponding author: Hongshan Wei
  • About author:
    Corresponding auther: Wei Hongshan, Email:
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蒋煜, 徐飞, 胡居龙, 华文浩, 李坪, 魏红山. 戊型肝炎患者血清GP73变化特征及意义[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(02): 179-182.

Yu Jiang, Xu Fei, Julong Hu, Wenhao Hua, Ping Li, Hongshan Wei. Characteristics of serum GP73 for patients with hepatitis E and its clinical significances[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(02): 179-182.

目的

观察戊型肝炎患者血清GP73变化特征。

方法

分析80例健康体检者（对照组）和66例戊型肝炎患者（观察组）血清GP73水平的变化。

结果

对照组研究对象血清GP73水平为（38.82 ± 15.67）ng/ml，观察组患者血清GP73为（80.06 ± 52.33）ng/ml，较对照组显著升高，差异具有统计学意义（t = 6.785、P < 0.00）；患者血清GP73水平与丙氨酸氨基转移酶（ALT）活性（r = 0.28、P = 0.015）、天门冬氨酸氨基转移酶（AST）活性（r = 0.36、P = 0.002）总胆红素（TBil）水平（r = 0.47、P < 0.001）均呈正相关，而与凝血酶原活动度（PTA）水平呈负相关（r =－0.329、P = 0.004）。

结论

血清GP73显著升高的人群需考虑急性戊型肝炎病毒感染的可能。戊型肝炎患者的血清GP73水平可能与肝功能损伤程度具有一定的相关性。

关键词: 肝炎，戊型, 高尔基体糖蛋白73, 肝功能损伤, 诊断
Objective

To investigate the variable characteristics of serum GP73 for patients with hepatitis E.

Methods

The changes of GP73 level in serum of 80 healthy subjects (control group) and 66 patients with hepatitis E were detected by quantitative enzyme-linked immunosorbent assay.

Results

The median level of serum GP73 for patients with hepatitis E (80.06 ± 52.33 ng/ml) was significantly increased than that of 80 healthy control subjects (38.82 ± 15.67 ng/ml), with significant difference (t = 6.785, P < 0.0001). The level of serum GP73 in patients with hepatitis E had positive correlation with the serum activity of alanine aminotransferase (ALT) (r = 0.28, P = 0.015), aspartate aminotransferase (AST) (r = 0.36, P = 0.002) and the level of serum total bilirubin (TBil) (r = 0.47, P < 0.001). While it had negative correlation with the prothrombin time activity (PTA) (r =-0.329, P = 0.004).

Conclusions

The possibility of acute hepatitis E infection should be considered for those who with significangly elevated serum GP73. Serum GP73 levels in patients with hepatitis E may be correlated with liver damage.

Key words: Hepatitis E, Golgi protein 73, Liver injury, Diagnosis
图1 两组研究对象血清GP73水平
图2 血清GP73水平与肝功能损伤主要指标的相关性
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