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中华实验和临床感染病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (02) : 125 -128. doi: 10.3877/cma.j.issn.1674-1358.2017.02.005

综述

乙型肝炎病毒rtA181位点变异特点及其临床意义
庞婷1, 邢卉春1,()   
  1. 1. 100015 北京,首都医科大学附属北京地坛医院肝病三科
  • 收稿日期:2016-02-27 出版日期:2017-04-15
  • 通信作者: 邢卉春
  • 基金资助:
    "十二五"国家科技重大专项(No. 2014ZX10005001); 首都特色应用研究项目(No. Z14110700250000); 北京市中医药科技项目(No. JJ2014-25); 北京市医院管理局扬帆计划项目(肝炎专业)(No. ZYLX2014-02); 登峰计划项目(肝病专业)(No. DFL20151701)

Features and clinical significance of rtA181 mutation of hepatitis B virus

Ting Pang1, Huichun Xing1,()   

  1. 1. Department of Hepatology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • Received:2016-02-27 Published:2017-04-15
  • Corresponding author: Huichun Xing
引用本文:

庞婷, 邢卉春. 乙型肝炎病毒rtA181位点变异特点及其临床意义[J]. 中华实验和临床感染病杂志(电子版), 2017, 11(02): 125-128.

Ting Pang, Huichun Xing. Features and clinical significance of rtA181 mutation of hepatitis B virus[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(02): 125-128.

核苷(酸)类似物(NAs)是目前治疗慢性乙型肝炎(CHB)的重要措施,但在治疗过程中不可避免地会出现耐药变异,严重影响临床疗效。rtA181位点变异为多药交叉耐药通路,影响病毒复制、HBsAg分泌,并且存在潜在发生肿瘤的风险。本文旨在对以上几点进行综述。

Patients with chronic hepatitis B (CHB) could be successfully treated using nucleos(t)ide analogues (NAs), but drug resistance mutations of hepatitis B virus (HBV) frequently arise which seriously affect the clinical efficacy. RtA181 mutation is a cross-resistant mutance, which affects viral replication and the secretion of HBsAg, it could also increase the risk of hepatoma occurrence. This article reviewed the above points.

表1 逆转录酶(rt)基因区变异相应的HBsAg变异
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