戊型肝炎病毒（HEV）感染可导致急、慢性病毒性肝炎和肝功能衰竭，同时与一系列肝外表现相关。神经系统损害是HEV感染最常见的肝外表现之一。近年来，关于戊型肝炎神经系统并发症的病例报道逐渐增多。吉兰-巴雷综合征和神经痛性肌萎缩是戊型肝炎病毒感染相关的主要的神经系统表现。急性戊型肝炎的神经系统并发症发病机制尚未明确。目前研究主要集中在病毒感染引起的免疫应答与病毒的直接作用两方面。本文对戊型肝炎病毒引起的神经系统表现及可能的发病机制进行综述。

Hepatitis E virus (HEV) infection could cause acute or chronic hepatitis and liver failure and is associated with a number of extrahepatic manifestations. Neurological injuries were one kind of the most common extrahepatic manifestations of HEV infection. In recent years, case reports on hepatitis E neurological complications increased gradually. Guillain-Barre syndrome and neuralgic amyotrophy were the main neurological manifestations associated with acute HEV infection. Pathogenesis of HEV related neurological manifestations were controversial. Current research focuses on immune mediated injury and HEV directly neurotropic injury. Hepatitis E virus associated neurological manifestations and possible pathogenesis were reviewed in this paper.