切换至 "中华医学电子期刊资源库"

中华实验和临床感染病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (01) : 17 -21. doi: 10.3877/cma.j.issn.1674-1358.2016.01.004

荟萃分析

幽门螺杆菌感染与非酒精性脂肪性肝病相关性的Meta分析
王璐1, 郝彦琴1, 赵龙凤1,()   
  1. 1. 030001 太原市,山西医科大学附属第一医院感染病科
  • 收稿日期:2015-04-27 出版日期:2016-02-15
  • 通信作者: 赵龙凤
  • 基金资助:
    山西省国际科技合作项目(No. 2014081053-2)

Meta-analysis of relationship between Helicobacter pylori infection and non-alcoholic fatty liver diseases

Lu Wang1, Yanqin Hao1, Longfeng Zhao1,()   

  1. 1. Department of Infectious Diseases, The First Affliated Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2015-04-27 Published:2016-02-15
  • Corresponding author: Longfeng Zhao
引用本文:

王璐, 郝彦琴, 赵龙凤. 幽门螺杆菌感染与非酒精性脂肪性肝病相关性的Meta分析[J/OL]. 中华实验和临床感染病杂志(电子版), 2016, 10(01): 17-21.

Lu Wang, Yanqin Hao, Longfeng Zhao. Meta-analysis of relationship between Helicobacter pylori infection and non-alcoholic fatty liver diseases[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(01): 17-21.

目的

评估幽门螺杆菌(Hp)感染与非酒精性脂肪性肝病的相关性。

方法

检索有关幽门螺杆菌感染与非酒精性脂肪性肝病相关性的研究文献。采用随机效应模型分析相关数据。

结果

共10篇文献入选。对其中符合病例对照研究的8篇文献进行二分类变量的Meta分析,得出研究间存在较大的异质性,且进行亚组分析无法解释异质性的来源,故尚无法通过Meta分析得出幽门螺杆菌感染与非酒精性脂肪性肝病间是否存在相关性。对10篇文献进行单组率的Meta分析,得出NAFLD患者中幽门螺杆菌感染率为47.7%(95%CI:0.334~0.620),较普通人群Hp感染率差异无统计学意义。

结论

尚需高质量的研究进一步验证Hp感染与非酒精性脂肪性肝病的相关性。

Objective

To assess the relationship between Helicobacter pylori (Hp) infection and non-alcoholic fatty liver diseases (NAFLD).

Methods

Articles that examined the association between Hp infection and NAFLD were searched. The certain data were pooled with a random-effects model.

Results

Ten trials were included, among which, eight case-control studies were carried on a binary variables meta analysis. It was concluded that due to the significant heterogeneity which failed to be explained by subgroup analysis, it was unable to use a meta-analysis to explore the relationship between Hp infection and NAFLD. A single rate meta-analysis was carried out on the ten studies, it is concluded that Hp infection rate in patients with NAFLD was 47.7% (95%CI: 0.334-0.620), which had no significant difference from the rate of general population.

Conclusions

High quality trials were needed to furtherly explore the relationship between Hp infection and NAFLD.

图1 文献选择流程图
表1 纳入研究的临床特征
图2 Hp感染与NAFLD关系的Meta分析森林图
表2 不同亚组间异质性检测
图3 8项有关Hp感染与NAFLD关系研究的漏斗图
图4 NAFLD患者中Hp感染率的Meta分析森林
图5 10项有关NAFLD患者中Hp感染率研究的漏斗图
[1]
Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori[J].Clin Microbiol Rev,1997,10(4):720-741.
[2]
王凯娟,王润田. 中国幽门螺杆菌感染流行病学Meta分析[J]. 中华流行病学杂志,2003,24(6):443-446.
[3]
Suzuki H, Marshall BJ, Hibi T. Overview: Helicobacter pylori and extragastric disease[J]. Int J Hematol,2006,84(4):291-300.

URL    
[4]
卢轶,沈哲,厉有名. 幽门螺杆菌感染和非酒精性脂肪性肝病的相关性分析:横断面研究[C]. 浙江大学医学院附属第一医院,2013.
[5]
郭晓燕,史海涛,师阿盟, 等. 非酒精性脂肪性肝病患者幽门螺杆菌感染状况调查[J]. 实用肝脏病杂志,2013,16(5):451-453.
[6]
刘安楠,王蕾蕾,张晏, 等. 非酒精性脂肪性肝病与幽门螺杆菌感染的相关性[J].胃肠病学和肝病学杂志,2014,23(12):1451-04.
[7]
彭朝阳,盛晓燕,丁海燕, 等. 幽门螺杆菌感染与非酒精性脂肪肝相关性研究[J]. 医学研究杂志,2014,43(6):153-156.
[8]
徐晖. 幽门螺杆菌感染与非酒精性脂肪性肝病的关系[J]. 中国美容医学,2011,20(6):69-70.
[9]
谭彦芳. 华北油田职工非酒精性脂肪性肝病患病率及相关危险因素分析[D]. 河北医科大学,2014.
[10]
Okushin K, Takahashi Y, Yamamichi N, et al. Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease:a large-scale cross-sectional study in Japan[J]. BMC Gastroenterol,2015,15:25
[11]
Polyzos SA, Kountouras J, Papatheodorou A, et al. Helicobacter pylori infection in patients with nonalcoholic fatty liver disease[J]. Metabolism,2013,62(1):121-126.

URL    
[12]
Sumida Y, Kanemasa K, Imai S, et al. Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease[J]. J Gastroenterol,2015,50(9):996-1004.
[13]
Polyzos SA, Nikolopoulos P, Stogianni A, et al. Effect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fibrosis score and HSENSI in patients with nonalcoholic steatohepatitis:a MR imaging-based pilot open-label study[J]. Arq Gastroenterol,2014,3(51):261-268.
[14]
中华医学会肝脏病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南(2010年修订版)[J]. 中华肝脏病杂志,2010,18(3):163-166.
[15]
Aydemir S, Bayraktaroglu T, Sert M, et al. The effect of Helicobacter pylori on insulin resistance[J]. Dig Dis Sci,2005,50(11):2090-2093.
[16]
Testerman TL, Morris J. Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment[J]. World J Gastroenterology,2014,20(36):12781-12808.

URL    
[1] 郝玥萦, 毛盈譞, 张羽, 汪佳旭, 韩林霖, 匡雯雯, 孟瑶, 杨秀华. 超声引导衰减参数成像评估肝脂肪变性及其对心血管疾病风险的预测价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 770-777.
[2] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[3] 蚁淳, 袁冬生, 熊学军. 系统免疫炎症指数与骨密度降低和骨质疏松的关联[J/OL]. 中华关节外科杂志(电子版), 2024, 18(05): 609-617.
[4] 李志文, 李远志, 李华, 方志远. 糖皮质激素治疗膝骨关节炎疗效的网状Meta分析[J/OL]. 中华关节外科杂志(电子版), 2024, 18(04): 484-496.
[5] 吴姗姗, 潘裕民, 刘晋, 张劲松, 乔莉. 睡眠呼吸暂停综合征患者静脉血栓栓塞症发生率的Meta分析[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 312-317.
[6] 崔玉峰, 林毅军, 王志民. 幽门螺杆菌分子检测技术研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(05): 257-262.
[7] 郭伟仪, 林沛玲. 不同抗体型幽门螺杆菌感染与溃疡性结肠炎患者疾病活动及组织学评分的关系[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 237-244.
[8] 沈华娟, 庄剑波, 刘春. 幽门螺杆菌感染抗体分型与胃黏膜炎性病变程度及黏膜组织学变化间的相关性[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(03): 156-162.
[9] 马振威, 宋润夫, 王兵. ERCP胆道内支架与骑跨十二指肠乳头支架置入治疗不可切除肝门部胆管癌疗效的Meta分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 807-812.
[10] 龚财芳, 赵俊宇, 游川. 围手术期肠内营养在肝癌肝切除患者中有效性及安全性的Meta分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 551-556.
[11] 王芳, 刘达, 左智炜, 盛金平, 陈庭进, 蒋锐. 定量CT与双能X线骨密度仪对骨质疏松诊断效能比较的Meta分析[J/OL]. 中华老年骨科与康复电子杂志, 2024, 10(06): 363-371.
[12] 杨卫东, 周威, 向洪涛. 慢性萎缩性胃炎患者幽门螺杆菌感染与炎性细胞因子及病理特征的关系[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 459-464.
[13] 周倩妹, 王宪娥, 徐筱, 老慧琳, 赵欣悦, 胡菁颖. 多元化系统护理对老年人群牙周健康指标影响的系统评价[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 500-506.
[14] 何妍, 檀丽冰, 周雯, 魏敏, 连军松. 老年男性人群幽门螺杆菌感染与血脂谱的关联研究[J/OL]. 中华胃肠内镜电子杂志, 2024, 11(03): 171-175.
[15] 张杨杨, 项楚淇, 朱满生. 肌少性肥胖与非酒精性脂肪性肝病间的关系以及研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(04): 276-282.
阅读次数
全文


摘要