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中华实验和临床感染病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (01) : 10 -12. doi: 10.3877/cma.j.issn.1674-1358.2016.01.002

综述

miRNA在肠道病毒71型手足口病诊断及治疗中的应用
邹容容1, 张国良2, 李建明2, 刘映霞1,()   
  1. 1. 518112 深圳市,南华大学深圳市第三人民医院感染科
    2. 深圳大学附属第三临床学院感染科
  • 收稿日期:2015-03-27 出版日期:2016-02-15
  • 通信作者: 刘映霞
  • 基金资助:
    广东省医学科研基金(No. A2014519); 深圳市新发传染病重点专科基金(No. 201161); 深圳市科技计划项目(No. JCYJ20140411112047888)

The application of miRNA in the diagnosis and treatment of hand, foot and mouth disease with EV71 infection

Rongrong Zou1, Guoliang Zhang2, Jianming Li2, Yingxia Liu1,()   

  1. 1. Department of Infectious Diseases, Shenzhen The Third People’s Hospital, University of South China, Shenzhen 518112, China
    2. The Third Affiliated Clinical College of Shenzhen University, Shenzhen 518112, China
  • Received:2015-03-27 Published:2016-02-15
  • Corresponding author: Yingxia Liu
引用本文:

邹容容, 张国良, 李建明, 刘映霞. miRNA在肠道病毒71型手足口病诊断及治疗中的应用[J]. 中华实验和临床感染病杂志(电子版), 2016, 10(01): 10-12.

Rongrong Zou, Guoliang Zhang, Jianming Li, Yingxia Liu. The application of miRNA in the diagnosis and treatment of hand, foot and mouth disease with EV71 infection[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(01): 10-12.

自2008年以来,手足口病(HFMD)疫情在我国多个地区流行,给我国公共卫生局面带来巨大挑战,而肠道病毒71型(EV71)是引起手足口病的主要病原体之一。微小RNA(microRNA)作为一种非编码单链RNA分子,通过调节病毒复制和基因表达在多种病毒感染性疾病的发生、发展和预后中发挥重要作用。本文就miRNA分子在EV71型HFMD诊断、治疗中的作用和研究进展作以综述。

Hand, foot and mouth disease (HFMD) is widely spread in China since 2008 and gives challenge to public health, and Enterovirus 71 (EV71) is one of the main pathogens of HFMD. As a non-coding, single stranded RNA, the miRNA (microRNA) plays important roles in virus infected diseases through regulating virus replication and gene expression. This paper reviewed about the application of miRNA in the diagnosis and treatment of HFMD with EV71 infection.

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