切换至 "中华医学电子期刊资源库"

中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (04) : 313 -315. doi: 10.3877/cma.j.issn.1674-1358.04.001

所属专题: 文献

综述

自噬在人类免疫缺陷病毒和结核分枝杆菌共同感染中的作用
张霞1, 付玉荣2, 李猛3, 孟祥英1, 高昆山4, 伊正君1,()   
  1. 1. 261053 潍坊市,山东省潍坊医学院医学检验学系;261031 潍坊市,山东省潍坊医学院附属医院检验科
    2. 261053 潍坊市,山东省潍坊医学院临床医学院微生物教研室
    3. 261053 潍坊市,山东省潍坊医学院医学检验学系
    4. 261031 潍坊市,山东省潍坊医学院附属医院检验科
  • 收稿日期:2017-12-22 出版日期:2018-08-15
  • 通信作者: 伊正君
  • 基金资助:
    山东省自然科学基金(No. ZR2016BL19)

Autophagy in human immunodeficiency virus and Mycobacterium tuberculosis coinfection

Xia Zhang1, Yurong Fu2, Meng Li3, Xiangying Meng1, Kunshan Gao4, Zhengjun Yi1,()   

  1. 1. Department of Laboratory Medicine, Shandong Province, Weifang 261053, China
    2. Department of Microbiology, Weifang Medical University, Shandong Province, Weifang 261053, China
    4. Clinical Laboratory of Affiliated Hospital of Weifang Medical University, Shandong Province, Weifang 261031, China
  • Received:2017-12-22 Published:2018-08-15
  • Corresponding author: Zhengjun Yi
  • About author:
    Corresponding Author: Yi Zhengjun, Email:
引用本文:

张霞, 付玉荣, 李猛, 孟祥英, 高昆山, 伊正君. 自噬在人类免疫缺陷病毒和结核分枝杆菌共同感染中的作用[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(04): 313-315.

Xia Zhang, Yurong Fu, Meng Li, Xiangying Meng, Kunshan Gao, Zhengjun Yi. Autophagy in human immunodeficiency virus and Mycobacterium tuberculosis coinfection[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(04): 313-315.

人类免疫缺陷病毒/结核分枝杆菌(HIV/M.tb)共同感染已经成为发展中国家的主要公共卫生威胁。自噬是一种溶酶体分解代谢过程,正常状态下维持细胞内环境的稳态,还涉及细胞内病原体如HIV-1和M.tb的清除,可增强机体的免疫防御能力。本文概述在HIV-1和M.tb单独感染以及共同感染的背景下自噬对机体免疫防御的调控,全面了解病原体与自噬的相互作用,展望未来开发基于自噬原理新的预防性疫苗和治疗干预措施的巨大潜力。

HIV/M.tb coinfection has become a major public health threat in developing countries. Autophagy is a process of lysosomal catabolism that maintains the homeostasis of the cell under normal conditions but also involves the clearance of intracellular pathogens such as HIV-1 and M.tb. It also enhances the host’s immune defense mechanisms against infectious diseases. This review summarizes the regulation of autophagy on immune defense in the context of HIV-1 and M.tb infection alone and coinfection, overviews the comprehensive understanding of the pathogen-autophagy interaction and highlights the future development concerning the new prophylaxis vaccines improvement and the great potential of therapeutic interventions based on the principle of autophagy.

[1]
World Health Organization. Global Tuberculosis Report 2016 [EB/OL]. Geneva: 2016.

URL    
[2]
Getahun H,Gunneberg C,Granich R, et al. HIV infection-associated tuberculosis: the epidemiology and the response[J]. Clin Infect Dis,2010,50(3):201-207.
[3]
World Health Organization. Global tuberculosis report 2017[EB/OL]. Geneva: 2017.

URL    
[4]
Lamb CA,Yoshimori T,Tooze SA, et al. The autophagosome: origins unknown, biogenesis complex[J]. Nat Rev Mol Cell Bio,2013,14(12):759-774.
[5]
Xu Y,Eissa NT. Autophagy in innate and adaptive immunity[J]. Proc Am Thorac Soc,2010,7(1):22-28.
[6]
Wang X,Gao Y,Tan J, et al. HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells[J]. Cell Signal,2012,24(7):1414-1419.
[7]
Espert L,Denizot M,Grimaldi M, et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4[J]. J Clin Invest,2006,116(8):2161-2172.
[8]
El-Hage N,Rodriguez M,Dever SM, et al. HIV-1 and morphine regulation of autophagy in Microglia: limited interactions in the context of HIV-1 infection and opioid abuse[J]. J Virol,2015,89(2):1024-1035.
[9]
Sagnier S,Daussy CF,Borel S, et al. Autophagy Restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes[J]. J Virol,2015,89(1):615-625.
[10]
Nardacci R,Amendola A,Ciccosanti F, et al. Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients[J]. Autophagy,2014,10(7):1167-1178.
[11]
Borel S,Robert-Hebmann V,Alfaisal J, et al. HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy[J]. AIDS,2015,29(3):275-286.
[12]
Li JC,Au K,Fang J, et al. HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction[J]. AIDS,2011,25(1):15-25.
[13]
North RJ,Jung YJ. Immunity to tuberculosis[J]. Annu Rev Immuno,2004,22(3569):599-623.
[14]
Ladel CH,Blum C,Dreher A, et al. Protective role of gamma/delta T cells and alpha/beta T cells in tuberculosis[J]. Eur J Immunol,1995,25(10):2877-2881.
[15]
Fratti RA,Chua J,Vergne I, et al. Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest[J]. Proc Natl Acad Sci USA,2003,100(9):5437-5442.
[16]
Vergne I,Fratti RA,Hill PJ, et al. Mycobacterium tuberculosis phagosome maturation arrest: Mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion[J]. Mol Biol Cell,2003,15(2):751-760.
[17]
Shui W,Petzold CJ,Redding AM, et al. Organelle membrane proteomics reveals differential influence of Mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation[J]. J Proteome Res,2011,10(1):339-348.
[18]
Seto S,Tsujimura K,Koide Y, et al. Coronin-1a inhibits autophagosome formation around Mycobacterium tuberculosis-containing phagosomes and assists mycobacterial survival in macrophages[J]. Cell Microbiol,2012,14(5):710-727.
[19]
Gomes LC,Dikic I. Autophagy in antimicrobial immunity.[J]. Mol Cell,2014,54(2):224-233.
[20]
Huang J,Brumell JH. Bacteria-autophagy interplay: a battle for survival[J]. Nat Rev Microbiol,2014,12(2):101-114.
[21]
Watson RO,Manzanillo P,Cox JS, et al. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway[J]. Cell,2012,150(4):803-815.
[22]
Manzanillo P,Ayres JS,Watson RO, et al. The ubiquitin ligase parkin mediates resistance to intracellular pathogens[J]. Nature,2013,501(7468):512-516.
[23]
Patel NR,Swan K,Li X, et al. Impaired M. tuberculosis-mediated apoptosis in alveolar macrophages from HIV+ persons: potential role of IL-10 and BCL-3[J]. J Leukoc Biol,2009,86(1):53-60.
[24]
Jasenosky LD,Scriba TJ,Hanekom WA, et al. T cells and adaptive immunity to Mycobacterium tuberculosis in humans[J]. Immunol Rev,2015,264(1):74-87.
[25]
Liu PT,Stenger S,Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response[J]. Science,2006,311(5768):1770-1773.
[26]
Borella E,Nesher G,Israeli E, et al. Vitamin D: a new anti-infective agent?[J]. Ann NY Acad Sci,2014,1317(1):76-83.
[27]
Yuk J,Shin D,Lee H, et al. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin[J]. Cell Host Microbe,2009,6(3):231-243.
[28]
Campbell GR,Spector SA. Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy[J]. PLoS Pathog,2012,8(5):e1002689.
[29]
Anandaiah A,Sinha S,Bole M, et al. Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals through an enhanced Toll-like receptor signaling pathway in vitro[J]. Infect Immun,2013,81(1):2-10.
[1] 李康, 冀亮, 赵维, 林乐岷. 自噬在乳腺癌生物学进展中的双重作用[J]. 中华乳腺病杂志(电子版), 2023, 17(04): 195-202.
[2] 吴茜, 邓力, 练士贤, 张华, 江颖, 张宏伟. 伴人类免疫缺陷病毒感染乳腺癌患者的临床病理特征与预后的相关性研究[J]. 中华乳腺病杂志(电子版), 2023, 17(03): 151-156.
[3] 孔莹莹, 谢璐涛, 卢晓驰, 徐杰丰, 周光居, 张茂. 丁酸钠对猪心脏骤停复苏后心脑损伤的保护作用及机制研究[J]. 中华危重症医学杂志(电子版), 2023, 16(05): 355-362.
[4] 周子慧, 李恭驰, 李炳辉, 王知, 刘慧真, 王卉, 邹利军. 细胞自噬在创面愈合中作用的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 542-546.
[5] 张永博, 张亮, 陈浏阳, 戴睿, 孙华, 杨盛, 孟博, 彭晴. 线粒体与椎间盘退变[J]. 中华损伤与修复杂志(电子版), 2023, 18(03): 265-269.
[6] 张玉, 薛文瑞, 王鑫, 李旭瑜, 王旭东, 袁鹏飞, 梁雨润, 韩志兴, 张海建, 刘庆军, 纪世琪. 人类免疫缺陷病毒感染合并膀胱癌14例临床特点[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(05): 354-358.
[7] 袁瑞, 胡文佳, 桂希恩, 严亚军, 冯玲, 柯亨宁, 熊勇, 杨蓉蓉. 淋巴细胞精细分型检测在人类免疫缺陷病毒感染者/获得性免疫缺陷综合征患者中的应用[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(02): 84-91.
[8] 崔贵香, 丁晓燕, 褚盈晖, 孙代, 吴海燕, 陈京龙. 57例人类免疫缺陷病毒感染合并Burkkit淋巴瘤患者的临床分析[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(02): 102-109.
[9] 钟文涛, 赵阳, 沈晓菲, 杜峻峰. 自噬在脓毒症中的作用及靶向治疗研究进展[J]. 中华普外科手术学杂志(电子版), 2023, 17(02): 221-225.
[10] 邵浩仁, 郭佳. 铁死亡的分子机制及其在前列腺癌治疗中的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(03): 294-298.
[11] 王希岗, 张波, 李鸣, 高敏, 薛建新. 神经外科手术部位感染在HIV感染者与非HIV感染者中的临床差异[J]. 中华神经创伤外科电子杂志, 2023, 09(04): 228-233.
[12] 王小红, 钱晶, 翁文俊, 周国雄, 朱顺星, 祁小鸣, 刘春, 王萍, 沈伟, 程睿智, 秦璟灏. 巯基丙酮酸硫基转移酶调控核因子κB信号介导自噬对重症急性胰腺炎大鼠的影响及机制[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 422-426.
[13] 郭如烨, 孟黎明, 陈楠, 宋玉莹, 尹海燕, 郭岩. Apelin/APJ系统对帕金森病模型的神经保护作用及机制研究进展[J]. 中华诊断学电子杂志, 2023, 11(04): 276-282.
[14] 李民昌, 马长林. 自噬调控的细胞铁死亡及在肿瘤中影响的研究进展[J]. 中华诊断学电子杂志, 2023, 11(02): 140-144.
[15] 邱甜, 杨苗娟, 胡波, 郭毅, 何奕涛. 亚低温治疗脑梗死机制的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 518-521.
阅读次数
全文


摘要