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中华实验和临床感染病杂志(电子版) ›› 2024, Vol. 18 ›› Issue (05) : 263 -269. doi: 10.3877/cma.j.issn.1674-1358.2024.05.002

综述

机械敏感性离子通道蛋白Piezo1在感染相关疾病中的研究进展
刘欢1,2, 邢皓1,2, 常正奇2,(), 张记3   
  1. 1.261031 潍坊市,山东第二医科大学临床医学院,山东第二医科大学
    2.250031 济南市,中国人民解放军联勤保障部队第九六〇医院骨病科
    3.400038 重庆,陆军军医大学基础医学院免疫学教研室
  • 收稿日期:2024-05-10 出版日期:2024-10-15
  • 通信作者: 常正奇
  • 基金资助:
    国家自然科学基金(No. 32270987)山东省自然科学基金(No. ZR202212010123)

Research progress on mechanosensitive ion channel protein Piezo1 in infection-related diseases

Huan Liu1,2, Hao Xing1,2, Zhengqi Chang2,(), Ji Zhang3   

  1. 1.School of Clinical Medicine, Shandong Second Medical University,Weifang 261053, China
    2.Department of Orthopedics, The 960th Hospital of PLA, Jinan 250031, China
    3.Department of Immunology, School of Basic Medical Sciences, Army Military Medical University, Chongqing 400038, China
  • Received:2024-05-10 Published:2024-10-15
  • Corresponding author: Zhengqi Chang
引用本文:

刘欢, 邢皓, 常正奇, 张记. 机械敏感性离子通道蛋白Piezo1在感染相关疾病中的研究进展[J]. 中华实验和临床感染病杂志(电子版), 2024, 18(05): 263-269.

Huan Liu, Hao Xing, Zhengqi Chang, Ji Zhang. Research progress on mechanosensitive ion channel protein Piezo1 in infection-related diseases[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2024, 18(05): 263-269.

Piezo1是一种新颖的机械敏感性离子通道蛋白(MSCP),于2010年在小鼠神经母细胞瘤细胞系Neuro2A中发现其由Fam38a基因编码。Piezo1广泛表达于多种脏器及细胞如肺、皮肤、膀胱、肾脏、内皮细胞和红细胞,其被机械刺激时激活,通过调控细胞内外Ca2+浓度进而调节下游胞内信号通路。近年来研究表明,Piezo1在感染性疾病的发生和发展中起着重要作用。本文主要从Piezo1的基本生理功能及调控机制、Piezo1在免疫细胞中的功能及Piezo1与感染相关疾病的关系方面进行综述,旨在为临床预防和治疗感染相关疾病提供新的诊疗思路。

Piezo1 is a novel mechanosensitive ion channel protein (MSCP), which was discovered in 2010 in the Neuro2A neuroblastoma cell line and encoded by the Fam38a gene. Piezo1 is widely expressed in various organs and cells, such as lung, skin, bladder, kidney, endothelial cells and red blood cells. It is activated by mechanical stimulation, regulating intracellular and extracellular Ca2+ concentration to modulate downstream intracellular signaling pathways. Recent studies have shown that Piezo1 plays an important role in the occurrence and development of infectious diseases. This article reviews the basic physiological functions and regulatory mechanisms of Piezo1, its functions in immune cells, and its relationship with infection-related diseases, which intended to provide new diagnostic and therapeutic strategies for the clinical prevention and treatment of infection-related diseases.

图1 Piezo1蛋白结构 注:Piezo1蛋白具有同源三聚体结构,在电镜结构中呈三叶螺旋桨结构
图2 Piezo1在不同感染性疾病中的作用
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