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中华实验和临床感染病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (04) : 217 -221. doi: 10.3877/cma.j.issn.1674-1358.2023.04.001

综述

单核细胞趋化蛋白-1在感染性疾病中研究进展
闫凯悦, 邓慧玲(), 张玉凤, 席淼, 李雨欣   
  1. 710003 西安市,西安市儿童医院感染二科
    710003 西安市,西安市中心医院
    710003 西安市,西安市儿童医院感染二科;710021 西安市,西安医学院
  • 收稿日期:2023-03-19 出版日期:2023-08-15
  • 通信作者: 邓慧玲
  • 基金资助:
    陕西省重点研发计划项目(No. 2022ZDLSF01-05); 西安市科技计划项目(No. 21YXYJ006)

Progress on monocyte chemoattractant protein-1 in infectious diseases

Kaiyue Yan, Huiling Deng(), Yufeng Zhang, Miao Xi, Yuxin Li   

  1. The Second Department of Infection, Xi’an Children’s Hospital, Xi’an 710003, China
    Xi’an Central Hospital, Xi’an 710003, China
    The Second Department of Infection, Xi’an Children’s Hospital, Xi’an 710003, China; Xi’an Medical College, Xi’an 710021, China
  • Received:2023-03-19 Published:2023-08-15
  • Corresponding author: Huiling Deng
引用本文:

闫凯悦, 邓慧玲, 张玉凤, 席淼, 李雨欣. 单核细胞趋化蛋白-1在感染性疾病中研究进展[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(04): 217-221.

Kaiyue Yan, Huiling Deng, Yufeng Zhang, Miao Xi, Yuxin Li. Progress on monocyte chemoattractant protein-1 in infectious diseases[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2023, 17(04): 217-221.

单核细胞趋化蛋白-1(MCP-1)是体内的一种趋化因子,主要由人体内淋巴细胞、单核巨噬细胞等多种细胞产生,通过作用于其相关受体而诱导免疫细胞参与炎症反应。MCP-1有多种生物学功能,早年国内外研究已发现其与临床多种常见疾病相关,如肺炎、脑炎、尿路感染、系统性红斑狼疮以及各种癌症等;近年来研究表明MCP-1参与多种感染性疾病的发生和发展,对临床疾病的诊断、评估及预后均起到重要作用。本文简要介绍MCP-1与多系统感染性疾病的研究进展,其中主要对MCP-1与儿童感染性疾病作详细叙述和介绍,阐述单核MCP-1与儿童常见感染性疾病的关联,为MCP-1应用于临床感染性疾病的诊断及治疗提供新帮助和新见解。

Monocyte chemotactic protein-1 (MCP-1) is a chemokine in vivo, which is mainly produced by lymphocytes, monocyte macrophages and other cells in human body. It induces immune cells to participate in inflammatory response by acting on its related receptors. MCP-1 has a variety of biological functions. Early domestic and foreign studies have found that MCP-1 is associated with a variety of common clinical diseases, such as pneumonia, encephalitis, urinary tract infection, systemic lupus erythematosus, various cancers, etc. Recent studies have shown that MCP-1 is involved in the occurrence and development of a variety of infectious diseases. It has played important roles to the diagnosis, evaluation and prognosis of clinical diseases. This paper will briefly introduce the research progress of MCP-1 and multi-system infectious diseases. In particular, MCP-1 and infectious diseases in children will be described in detail, and the association between MCP-1 and common infectious diseases in children will be expounded. It provides new help and insight for the application of MCP-1 in the diagnosis and treatment of infectious diseases.

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