调查医院门诊机会性筛查女性人乳头瘤病毒（HPV）感染流行病学分布和对预防性疫苗的认知情况，为本院宫颈病变防治提供依据。

收集2017年1月至2017年12月于湖北医药学院附属随州医院妇科门诊行HPV筛查的女性患者的流行病学资料，采用问卷调查以了解其对HPV感染及疫苗接种的认知情况。

本院门诊机会性筛查女性HPV感染率为16.55%（143/864）。不同年龄组女性HPV感染率差异有统计学意义（χ² = 23.61、P < 0.001）。HPV感染基因型以单一型感染多见（73.43%）；多重感染占26.57%（38/143）；高危型感染占70.63%，以HPV 16型、58型和52型多见，低危型占29.37%，以HPV 81型、11型和42型多见。在问卷调查中，女性对于HPV感染的认知与年龄和文化程度有关（χ² = 70.89、70.63，P均< 0.001），与居住地无关（χ² = 1.85、P = 0.17）。27.39%（309/1 128）人群知晓HPV感染，20.12%（227/1 128）知晓HPV疫苗，37.59%（424/1 128）人群愿意接种HPV疫苗，其中仅12%（51/424）愿意自费接种；疫苗价位是影响HPV疫苗接受度的主要因素。

本医院机会性筛查女性人群HPV感染率较高，同时对HPV认知和预防意识较低。应加强HPV筛查的普查力度，积极推广HPV疫苗的知晓率和接受度。

To investigate the epidemiological distribution of human papillomavirus (HPV) infection and the knowledge of prophylactic vaccine in outpatient screening of female population, and to provide evidence for the prevention and treatment of cervical lesions.

Epidemiological data of female patients who were screened for HPV in gynecological outpatient clinic of Suizhou Hospital Affiliated to Hubei University of Medicine from January 2017 to December 2017 were collected and their cognition of HPV and vaccination were investigated by questionnaire.

The infection rate of HPV in outpatient opportunistic screening was 16.55% (143/864). There was significant difference in HPV infection rate among different age groups (χ² = 23.61, P < 0.001). The genotypes of HPV infection were mostly single-type infection (73.43%), multiple genotypes infection accounted for 26.57% (38/143). High risk subtype infection accounted for 70.63%, the most subtypes of which were HPV16, 58 and 52; the low risk type accounted for 29.37%, among which, HPV 81, 11 and 42 were the most common. In the questionnaire survey, HPV cognition was correlated with age and educational level (χ² = 70.89, 70.63; all P < 0.001), but was not related to household registration (χ² = 1.85, P = 0.17). There were 27.39% (309/1 128) investigated crowd knew HPV infection, 20.12% (227/ 1 128) knew HPV vaccine, 37.59% (424/1 128) were willing to be vaccinated, only 12% (51/424) of them were willing to be vaccinated at their own expense; the price of HPV vaccine is the main factor affecting the acceptance.

HPV infection rate was high and the awareness and prevention of HPV was low among the female population with opportunistic screening. The precancerous screening of HPV should be strengthened and the awareness and acceptance of HPV vaccine should be actively promoted.