探讨颌面部间隙感染者病因，临床体征及综合治疗方法。

选取2014年1月至2016年12月于惠州市中心人民医院接受治疗的符合临床口腔颌面间隙感染(MSI)纳入条件的共126例患者。对患者病因、全身状况、致病菌、年龄、治疗以及诊断等进行系统性分析。

不同年龄段MSI感染者例数(χ²= 12.903、P= 0.030)，不同感染源患者例数(χ²= 11.17、P= 0.03)，不同感染部位患者例数(χ²= 14.31、P = 0.02)，不同致病菌所致感染者例数(χ²= 12.41、P = 0.02)，差异均有统计学意义。126例患者经抗菌药物保守治疗后，41例患者痊愈出院；经药物治疗和切口引流治疗，85例患者未出现明显并发症。不同治疗方式的患者例数差异具有统计学意义(χ²= 8.91、P= 0.04)。患者炎性因子白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平均较治疗前下降，差异有统计学意义(P均< 0.05)。

颌面部间隙感染者需要及时应用足量、敏感抗菌药物，并及时对脓肿切开引流，可控制颌面部间隙感染发展。

To investigate the etiology, clinical characteristics and comprehensive treatment of maxillofacial space infection.

Total of 126 patients with oral and maxillofacial space infection (MSI) who were treated in Huizhou Central people’s Hospital from January 2014 to December 2016 were selected. The etiology, systemic condition, pathogenic bacteria, age, treatment and diagnosis were systematically analyzed, resptectively.

There was significant difference in the number of cases with MSI infection in different age grades (χ²= 12.903,P = 0.030), the number of different infection sources (χ²= 11.17, P= 0.03), different infection sites (χ²= 14.31,P= 0.02) and different pathogenic bacteria (χ²= 12.41,P= 0.02). All 126 patients were cured by antimicrobial conservative therapy, among whom 41 patients were discharged from hospital, and 85 patients were without obvious complications after drug and incision drainage treatment. There was significant difference among the number of patients with different treatmentmethods (χ²= 8.91,P = 0.04). The levels of inflammatory cytokine interleukin-1 (IL-1), interleukin-6 (IL-6),C-reactive protein (CRP) and tumor necrosis factor-α(TNF-α) were significantly lower than those before treatment, with significant differences (allP < 0. 05).

In order to control the development of maxillofacial space infection, patients with maxillofacial space infection should be given adequate and sensitive antibiotics and timely incision and drainage of abscess.