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中华实验和临床感染病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (06) : 622 -624. doi: 10.3877/cma.j.issn.1674-1358.2017.06.021

病例报告

嗜肺军团菌肺炎合并横纹肌溶解症的诊断治疗及国内文献复习
田国保1, 李珺1, 董建平1,(), 耿燕1   
  1. 1. 100080 北京,北京市海淀医院(北京大学第三医院海淀院区)感染性疾病科
  • 收稿日期:2017-01-28 出版日期:2017-12-15
  • 通信作者: 董建平
  • 基金资助:
    北京市科技计划基金项目(No. D151100002115004)

Diagnosis and treatment of Legionella pneumonia complicated with rhabdomyolysis and review of Chinese literatures

Guobao Tian1, Jun Li1, Jianping Dong1,(), Yan Geng1   

  1. 1. Department of Infectious Disease, Beijing Haidian Hospital, Beijing Haidian Section of Peking University Third Hospital, Beijing 100080, China
  • Received:2017-01-28 Published:2017-12-15
  • Corresponding author: Jianping Dong
引用本文:

田国保, 李珺, 董建平, 耿燕. 嗜肺军团菌肺炎合并横纹肌溶解症的诊断治疗及国内文献复习[J/OL]. 中华实验和临床感染病杂志(电子版), 2017, 11(06): 622-624.

Guobao Tian, Jun Li, Jianping Dong, Yan Geng. Diagnosis and treatment of Legionella pneumonia complicated with rhabdomyolysis and review of Chinese literatures[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(06): 622-624.

目的

探讨嗜肺军团菌肺炎并发横纹肌溶解症的诊断和治疗,以改善患者的预后。

方法

分析一例嗜肺军团菌肺炎并发横纹肌溶解症的临床表现与诊治过程,检索2006至2016年共10年的国内文献进行复习。

结果

一例嗜肺军团菌并发横纹肌溶解症患者男性,肌酸激酶(CK)为2 171 U/L,肌红蛋白(MYO)为313 ng/ml,血肌酐水平正常,给予积极补液、碱化尿液、利尿等对症治疗后CK及Myo恢复正常。国内文献共检索嗜肺军团菌并发横纹肌溶解症病例5例,年龄26~82岁,男性4例、女性1例,3例患者有使用空调史,其CK水平为1 641~13 600 U/L,4例患者肌酐升高168~699 μmol/L,均给予了补液、碱化尿液、利尿对症,3例患者接受连续性床旁血滤支持治疗后肾功能恢复正常。

结论

嗜肺军团菌肺炎并发横纹肌溶解症临床少见,早期诊断、及时有效地针对病原学和并发症治疗有助于改善预后。

Objective

To investigate the diagnosis and treatment of Legionella pneumonia complicated with rhabdomyolysis and to improve the prognosis of patients.

Methods

The clinical manifestation and treatment process of one patients with Legionella pneumonia complicated with rhabdomyolysis were analyzed, and the literature retrieved from 2006 to 2016 and were reviewed.

Results

The case of Legionella pneumophila complicated with rhabdomyolysis was male, whose level of creatine kinase (CK) and myoglobin (MYO) were elevated by 2 171 U/L and 313 ng/ml, repectively, serum creatinine was normal. The levels of CK and MYO returned to normal after symptomatic treatment such as positive fluid replacement, alkalization of urine and diureses. Total 5 cases of Legionella pneumophila complicated with rhabdomyolysis have been retrieved from the literatures, with the age 26-82 years old, and 4 cases were male. Among them, 3 cases had the history of air-conditioning, the levels of CK were 1 641-13 600U/L, 4 patients with elevated creatinine (168-699 μmol/L). All patients had received rehydration, alkaline urine, diuretic symptomatic treatment. The renal function of 3 cases returned to normal after continuous bedside hemofiltration support.

Conclusions

Legionella pneumophila complicated with rhabdomyolysis is rare. Early diagnosis, timely and effective treatment of etiology and complications could help to improve the prognosis.

图1 患者入院时(病程10 d)肺部CT示左肺下叶炎症渗出期
图2 患者入院2周后出院前(病程24 d)肺部CT示左肺下叶炎症实变期
图3 患者病程52 d肺部CT示左肺下叶炎症吸收期
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